You are not logged in.

Erythropoietin does not enhance skeletal muscle protein synthesis following exercise in young and older adults

Lamon, Severine, Zacharewicz, Evelyn, Arentson-Lantz, Emily, Della Gatta, Paul A., Ghobrial, Lobna, Gerlinger Romero, Frederico, Garnham, Andrew, Paddon-Jones, Douglas and Russell, Aaron P. 2016, Erythropoietin does not enhance skeletal muscle protein synthesis following exercise in young and older adults, Frontiers in physiology, vol. 7, Article number : 292, pp. 1-8, doi: 10.3389/fphys.2016.00292.

Attached Files
Name Description MIMEType Size Downloads

Title Erythropoietin does not enhance skeletal muscle protein synthesis following exercise in young and older adults
Author(s) Lamon, Severine
Zacharewicz, Evelyn
Arentson-Lantz, Emily
Della Gatta, Paul A.
Ghobrial, Lobna
Gerlinger Romero, Frederico
Garnham, Andrew
Paddon-Jones, Douglas
Russell, Aaron P.
Journal name Frontiers in physiology
Volume number 7
Season Article number : 292
Start page 1
End page 8
Total pages 8
Publisher Frontiers Research Foundation
Place of publication Lausanne, Switzerland
Publication date 2016-07
Keyword(s) aging
anabolic signaling
muscle protein synthesis
resistance exercise
Summary PURPOSE: Erythropoietin (EPO) is a renal cytokine that is primarily involved in hematopoiesis while also playing a role in non-hematopoietic tissues expressing the EPO-receptor (EPOR). The EPOR is present in human skeletal muscle. In mouse skeletal muscle, EPO stimulation can activate the AKT serine/threonine kinase 1 (AKT) signaling pathway, the main positive regulator of muscle protein synthesis. We hypothesized that a single intravenous EPO injection combined with acute resistance exercise would have a synergistic effect on skeletal muscle protein synthesis via activation of the AKT pathway. METHODS: Ten young (24.2 ± 0.9 years) and 10 older (66.6 ± 1.1 years) healthy subjects received a primed, constant infusion of [ring-13C(6)] L-phenylalanine and a single injection of 10,000 IU epoetin-beta or placebo in a double-blind randomized, cross-over design. 2 h after the injection, the subjects completed an acute bout of leg extension resistance exercise to stimulate skeletal muscle protein synthesis. RESULTS: Significant interaction effects in the phosphorylation levels of the members of the AKT signaling pathway indicated a differential activation of protein synthesis signaling in older subjects when compared to young subjects. However, EPO offered no synergistic effect on vastus lateralis mixed muscle protein synthesis rate in young or older subjects. CONCLUSIONS: Despite its ability to activate the AKT pathway in skeletal muscle, an acute EPO injection had no additive or synergistic effect on the exercise-induced activation of muscle protein synthesis or muscle protein synthesis signaling pathways.
Language eng
DOI 10.3389/fphys.2016.00292
Field of Research 110602 Exercise Physiology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, The Authors
Persistent URL

Document type: Journal Article
Collections: School of Exercise and Nutrition Sciences
Open Access Checking
Connect to link resolver
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in TR Web of Science
Scopus Citation Count Cited 0 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 17 Abstract Views, 1 File Downloads  -  Detailed Statistics
Created: Thu, 20 Oct 2016, 09:27:00 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact