Oxidized fish oil in rat pregnancy causes high newborn mortality and increases maternal insulin resistance

Albert, Benjamin B., Vickers, Mark H., Gray, Clint, Reynolds, Clare M., Segovia, Stephanie A., Derraik, José G. B., Lewandowski, Paul A., Garg, Manohar L., Cameron-Smith, David, Hofman, Paul L. and Cutfield, Wayne S. 2016, Oxidized fish oil in rat pregnancy causes high newborn mortality and increases maternal insulin resistance, American journal of physiology. Regulatory, integrative and comparative physiology, vol. 311, no. 3, pp. R497-R504, doi: 10.1152/ajpregu.00005.2016.

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Title Oxidized fish oil in rat pregnancy causes high newborn mortality and increases maternal insulin resistance
Author(s) Albert, Benjamin B.
Vickers, Mark H.
Gray, Clint
Reynolds, Clare M.
Segovia, Stephanie A.
Derraik, José G. B.
Lewandowski, Paul A.
Garg, Manohar L.
Cameron-Smith, David
Hofman, Paul L.
Cutfield, Wayne S.
Journal name American journal of physiology. Regulatory, integrative and comparative physiology
Volume number 311
Issue number 3
Start page R497
End page R504
Total pages 8
Publisher American Physiological Society
Place of publication Bethesda, Md.
Publication date 2016-09-01
ISSN 0363-6119
Keyword(s) dams
lipid peroxides
n-3 polyunsaturated fatty acids
Science & Technology
Life Sciences & Biomedicine
Summary Fish oil is commonly taken by pregnant women, and supplements sold at retail are often oxidized. Using a rat model, we aimed to assess the effects of supplementation with oxidized fish oil during pregnancy in mothers and offspring, focusing on newborn viability and maternal insulin sensitivity. Female rats were allocated to a control or high-fat diet and then mated. These rats were subsequently randomized to receive a daily gavage treatment of 1 ml of unoxidized fish oil, a highly oxidized fish oil, or control (water) throughout pregnancy. At birth, the gavage treatment was stopped, but the same maternal diets were fed ad libitum throughout lactation. Supplementation with oxidized fish oil during pregnancy had a marked adverse effect on newborn survival at day 2, leading to much greater odds of mortality than in the control (odds ratio 8.26) and unoxidized fish oil (odds ratio 13.70) groups. In addition, maternal intake of oxidized fish oil during pregnancy led to increased insulin resistance at the time of weaning (3 wks after exposure) compared with control dams (HOMA-IR 2.64 vs. 1.42; P = 0.044). These data show that the consumption of oxidized fish oil is harmful in rat pregnancy, with deleterious effects in both mothers and offspring.
Language eng
DOI 10.1152/ajpregu.00005.2016
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, the American Physiological Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30087673

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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