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Marsupial tammar wallaby delivers milk bioactives to altricial pouch young to support lung development

Modepalli, Vengamanaidu, Hinds, Lyn A., Sharp, Julie A., Lefevre, Christophe and Nicholas, Kevin R. 2016, Marsupial tammar wallaby delivers milk bioactives to altricial pouch young to support lung development, Mechanisms of development, vol. 142, pp. 22-29, doi: 10.1016/j.mod.2016.08.004.

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Title Marsupial tammar wallaby delivers milk bioactives to altricial pouch young to support lung development
Author(s) Modepalli, Vengamanaidu
Hinds, Lyn A.
Sharp, Julie A.ORCID iD for Sharp, Julie A. orcid.org/0000-0002-4481-5223
Lefevre, Christophe
Nicholas, Kevin R.
Journal name Mechanisms of development
Volume number 142
Start page 22
End page 29
Total pages 8
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2016-11
ISSN 1872-6356
Keyword(s) Evolution
Lactation
Lung development
Marsupials
Milk
Science & Technology
Life Sciences & Biomedicine
Developmental Biology
POSTNATAL LUNG
FETAL-GROWTH
MONODELPHIS-DOMESTICA
MORPHOMETRIC-ANALYSIS
ENDOCRINE REGULATION
PULMONARY-FIBROSIS
EXPRESSION
MODEL
PDGF
MORPHOGENESIS
Summary Our research is exploiting the marsupial as a model to understand the signals required for lung development. Marsupials have a unique reproductive strategy, the mother gives birth to altricial neonate with an immature lung and the changes in milk composition during lactation in marsupials appears to provide bioactives that can regulate diverse aspects of lung development, including branching morphogenesis, cell proliferation and cell differentiation. These effects are seen with milk collected between 25 and 100days postpartum. To better understand the temporal effects of milk composition on postnatal lung development we used a cross-fostering technique to restrict the tammar pouch young to milk composition not extending beyond day 25 for 45days of its early postnatal life. These particular time points were selected as our previous study showed that milk protein collected prior to ~day 25 had no developmental effect on mouse embryonic lungs in culture. The comparative analysis of the foster group and control young at day 45 postpartum demonstrated that foster pouch young had significantly reduced lung size. The lungs in fostered young were comprised of large intermediate tissue, had a reduced size of airway lumen and a higher percentage of parenchymal tissue. In addition, expression of marker genes for lung development (BMP4, WNT11, AQP-4, HOPX and SPB) were significantly reduced in lungs from fostered young. Further, to identify the potential bioactive expressed by mammary gland that may have developmental effect on pouch young lungs, we performed proteomics analysis on tammar milk through mass-spectrometry and listed the potential bioactives (PDGF, IGFBP5, IGFBPL1 and EGFL6) secreted in milk that may be involved in regulating pouch young lung development. The data suggest that postnatal lung development in the tammar young is most likely regulated by maternal signalling factors supplied through milk.
Language eng
DOI 10.1016/j.mod.2016.08.004
Field of Research 099999 Engineering not elsewhere classified
06 Biological Sciences
11 Medical And Health Sciences
Socio Economic Objective 0 Not Applicable
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2016, Elsevier Ireland Ltd
Persistent URL http://hdl.handle.net/10536/DRO/DU:30087858

Document type: Journal Article
Collection: School of Medicine
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