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Reductions in water and sodium intake by aged male and female rats

Begg, Denovan P., Sinclair, Andrew J. and Weisinger, Richard S. 2012, Reductions in water and sodium intake by aged male and female rats, Nutrition research, vol. 32, no. 11, pp. 865-872, doi: 10.1016/j.nutres.2012.09.014.

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Title Reductions in water and sodium intake by aged male and female rats
Author(s) Begg, Denovan P.
Sinclair, Andrew J.
Weisinger, Richard S.
Journal name Nutrition research
Volume number 32
Issue number 11
Start page 865
End page 872
Total pages 8
Publisher Elsevier
Place of publication New York, N.Y.
Publication date 2012-11
ISSN 0271-5317
1879-0739
Keyword(s) aging
thirst
sodium appetite
renin-angiotensin system
atrial natriuretic factor
sex differences
rat
Age Factors
Angiotensin II
Animals
Drinking
Female
Hot Temperature
Hypothalamus
Male
RNA, Messenger
Rats
Rats, Inbred Strains
Receptor, Angiotensin, Type 1
Sex Factors
Sodium
Sodium Chloride
Sodium Chloride, Dietary
Water
Water Deprivation
Science & Technology
Life Sciences & Biomedicine
Nutrition & Dietetics
ATRIAL-NATRIURETIC-PEPTIDE
HEALTHY ELDERLY MEN
BROWN-NORWAY RATS
SEX-DIFFERENCES
GENE-EXPRESSION
FLUID INGESTION
REDUCED THIRST
ANGIOTENSIN-II
OSMOTIC THIRST
SALT APPETITE
Summary Aging results in reduced water and sodium intake responses in male rats. Because sex differences exist for water and sodium ingestion of young adult animals, we hypothesized that these sex differences would protect against the diminished water and sodium ingestion of aged female rats. Water and sodium intakes were examined in male and female young adult and aged Brown Norway rats in response to dipsogenic stimuli. Aged rats of both sexes consumed less water than young adult rats in response to 24-h water deprivation, thermal dehydration and hypertonic NaCl injection, but not to peripheral angiotensin II. Aged females consumed more water than males in response to hypertonic NaCl injection. Following sodium depletion, intake of 0.5 M NaCl solution over 2 h was higher in young adult rats than in aged rats. Aged animals had reduced angiotensin receptor 1A (AT1A) and atrial natriuretic peptide (ANP) mRNA expression in hypothalamic tissue with no sex differences. These data indicate that female rats are not protected from water and sodium intake deficits that occur in aging and that sex differences in sodium intake in young adult rats are eliminated with aging.
Language eng
DOI 10.1016/j.nutres.2012.09.014
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
1111 Nutrition And Dietetics
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2012, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30088060

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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