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Postprandial responses to lipid and carbohydrate ingestion in repeated subcutaneous adipose tissue biopsies in healthy adults

Dordevic, Aimee L., Pendergast, Felicity J., Morgan, Han, Villas-Boas, Silas, Caldow, Marissa K., Larsen, Amy E., Sinclair, Andrew J. and Cameron-Smith, David 2015, Postprandial responses to lipid and carbohydrate ingestion in repeated subcutaneous adipose tissue biopsies in healthy adults, Nutrients, vol. 7, no. 7, pp. 5347-5361, doi: 10.3390/nu7075224.

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Title Postprandial responses to lipid and carbohydrate ingestion in repeated subcutaneous adipose tissue biopsies in healthy adults
Author(s) Dordevic, Aimee L.
Pendergast, Felicity J.
Morgan, Han
Villas-Boas, Silas
Caldow, Marissa K.
Larsen, Amy E.
Sinclair, Andrew J.
Cameron-Smith, David
Journal name Nutrients
Volume number 7
Issue number 7
Start page 5347
End page 5361
Total pages 15
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2015-07-01
ISSN 2072-6643
Keyword(s) adipokine
adipose tissue
biopsy
inflammation
postprandial
Adult
Beverages
Body Mass Index
Chemokine CCL2
Dietary Carbohydrates
Dietary Fats
Drinking Water
Eating
Female
Healthy Volunteers
Humans
Interleukin-6
Leptin
Lipids
Male
Postprandial Period
Subcutaneous Fat, Abdominal
Time Factors
Tumor Necrosis Factor-alpha
Young Adult
Summary Adipose tissue is a primary site of meta-inflammation. Diet composition influences adipose tissue metabolism and a single meal can drive an inflammatory response in postprandial period. This study aimed to examine the effect lipid and carbohydrate ingestion compared with a non-caloric placebo on adipose tissue response. Thirty-three healthy adults (age 24.5 ± 3.3 year (mean ± standard deviation (SD)); body mass index (BMI) 24.1 ± 3.2 kg/m2, were randomised into one of three parallel beverage groups; placebo (water), carbohydrate (maltodextrin) or lipid (dairy-cream). Subcutaneous, abdominal adipose tissue biopsies and serum samples were collected prior to (0 h), as well as 2 h and 4 h after consumption of the beverage. Adipose tissue gene expression levels of monocyte chemoattractant protein-1 (MCP-1), interleukin 6 (IL-6) and tumor necrosis factor-α (TNF-α) increased in all three groups, without an increase in circulating TNF-α. Serum leptin (0.6-fold, p = 0.03) and adipose tissue leptin gene expression levels (0.6-fold, p = 0.001) decreased in the hours following the placebo beverage, but not the nutrient beverages. Despite increased inflammatory cytokine gene expression in adipose tissue with all beverages, suggesting a confounding effect of the repeated biopsy method, differences in metabolic responses of adipose tissue and circulating adipokines to ingestion of lipid and carbohydrate beverages were observed.
Language eng
DOI 10.3390/nu7075224
Field of Research 1111 Nutrition And Dietetics
Socio Economic Objective 0 Not Applicable
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2015, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30088064

Document type: Journal Article
Collections: School of Exercise and Nutrition Sciences
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.