You are not logged in.

Surgery for colonic cancer in HNPCC: total vs segmental colectomy

Stupart, Douglas A., Goldberg, P. A., Baigrie, R. J., Algar, U. and Ramesar, R. 2011, Surgery for colonic cancer in HNPCC: total vs segmental colectomy, Colorectal disease, vol. 13, no. 12, pp. 1395-1399, doi: 10.1111/j.1463-1318.2010.02467.x.

Attached Files
Name Description MIMEType Size Downloads

Title Surgery for colonic cancer in HNPCC: total vs segmental colectomy
Formatted title Surgery for colonic cancer in HNPCC: total vs segmental colectomy
Author(s) Stupart, Douglas A.
Goldberg, P. A.
Baigrie, R. J.
Algar, U.
Ramesar, R.
Journal name Colorectal disease
Volume number 13
Issue number 12
Start page 1395
End page 1399
Total pages 5
Publisher Wiley
Place of publication Chichester, Eng.
Publication date 2011-12
ISSN 1462-8910
1463-1318
Keyword(s) HNPCC
Lynch syndrome
metachronous colorectal cancers
Summary Aim: The high reported risk of metachronous colon cancer (MCC) in hereditary nonpolyposis colorectal cancer (HNPCC) has led some authors to recommend total colectomy (TC) as the preferred operation for primary colon cancer, but this remains controversial. No previous study has compared survival after TC with segmental colectomy (SC) in HNPCC. The aim of this study was to determine the risk of developing MCC in patients with genetically proven HNPCC after SC or TC for cancer, and to compare their long-term survival.

Method: This is a prospective cohort study of all patients referred to our unit between 1995 and 2009 with a proven germline mismatch repair gene defect, who had undergone a resection for adenocarcinoma of the colon with curative intent. All patients were offered annual endoscopic surveillance.

Results: Of 60 patients in the study, 39 had TC as their initial surgery and 21 had SC. After 6 years follow up, MCC occurred in eight (21%) SC patients and in none of the TC patients (P = 0.048). The risk of developing MCC after SC was 20% at 5 years. Colorectal cancer-specific survival was better in TC patients (P = 0.048) but overall survival of the two groups was similar (P = 0.29).

Conclusion: Patients with HNPCC have a significant risk of MCC after SC. This is eliminated by performing TC as the primary operation for colonic cancer.
Language eng
DOI 10.1111/j.1463-1318.2010.02467.x
Field of Research 111799 Public Health and Health Services not elsewhere classified
1103 Clinical Sciences
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2011, Association of Coloproctology of Great Britain and Ireland
Persistent URL http://hdl.handle.net/10536/DRO/DU:30088106

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in TR Web of Science
Scopus Citation Count Cited 9 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 8 Abstract Views, 1 File Downloads  -  Detailed Statistics
Created: Tue, 28 Mar 2017, 15:42:44 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.