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Acetylacetonato chelated ruthenium organometallics incorporating imine-phenol function: spectroscopic, structural, electrochemical and cytotoxicity studies

Mallick, Suman, Ghosh, Mrinal Kanti, Sarkar, Ananda, Jana, Samir, Bhattacharyya, Arindam, Mohapatra, Sudip and Chattopadhyay, Swarup 2015, Acetylacetonato chelated ruthenium organometallics incorporating imine-phenol function: spectroscopic, structural, electrochemical and cytotoxicity studies, Inorganica chimica acta, vol. 430, pp. 36-45, doi: 10.1016/j.ica.2015.02.023.

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Title Acetylacetonato chelated ruthenium organometallics incorporating imine-phenol function: spectroscopic, structural, electrochemical and cytotoxicity studies
Author(s) Mallick, Suman
Ghosh, Mrinal Kanti
Sarkar, Ananda
Jana, Samir
Bhattacharyya, Arindam
Mohapatra, Sudip
Chattopadhyay, Swarup
Journal name Inorganica chimica acta
Volume number 430
Start page 36
End page 45
Total pages 10
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2015-05-01
ISSN 0020-1693
1873-3255
Keyword(s) ruthenium
iminium–phenolato
redox chemistry
cytotoxicity
theoretical study
Summary The heterogeneous phase reaction of Ru(η2-RL)(PPh3)2(CO)Cl, 1 with lithium acetylacetonate (Liacac) afforded the complexes of the type Ru(η1-RL)(PPh3)2(CO)(acac), 2 in excellent yield where η2-RL is C6H2O-2-CHNHC6H4R(p)-3-Me-5 and η1-RL is C6H2OH-2-CHNC6H4R(p)-3-Me-5 and R is H, Me, Cl. The chelation of acac is attended with the cleavage of Ru-O and Ru-Cl bonds and iminium-phenolato → imine-phenol prototropic shift. A sterically controlled change in rotational conformation is involved in the 12 conversion. The conversion is irreversible and the type 2 species are thermodynamically more stable than the carboxylate, nitrite and nitrate complexes of 1. The crystal structures of Ru(η1-MeL)(PPh3)2(CO)(acac), 2(Me) and Ru(η1-ClL)(PPh3)2(CO)(acac), 2(Cl) are reported. Spectral (UV-Vis, IR, 1H NMR) and electrochemical data of the complexes are also reported. The electronic structure and the absorption spectra of the complexes are scrutinized by the density functional theory (DFT) and time-dependent density functional theory (TD-DFT) analyses. The complexes were also screened in vitro for their antiproliferative properties against the MCF-7 breast cancer cell lines by using the MTT assay. Flow cytometric analysis showed that the complexes arrested the cell cycle in the sub G0 phase.
Language eng
DOI 10.1016/j.ica.2015.02.023
Field of Research 030199 Analytical Chemistry not elsewhere classified
0302 Inorganic Chemistry
0399 Other Chemical Sciences
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30088338

Document type: Journal Article
Collection: School of Life and Environmental Sciences
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