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Chasing the personalized medicine dream through biomarker validation in colorectal cancer.

Patil, Harshali Anant, Saxena, Shailaja G, Barrow, Colin, Kanwar, Jagat, Kapat, Arnab and Kanwar, Rupinder 2016, Chasing the personalized medicine dream through biomarker validation in colorectal cancer., Drug discovery today, In Press, pp. 1-9, doi: 10.1016/j.drudis.2016.09.022.

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Title Chasing the personalized medicine dream through biomarker validation in colorectal cancer.
Author(s) Patil, Harshali Anant
Saxena, Shailaja G
Barrow, Colin
Kanwar, Jagat
Kapat, Arnab
Kanwar, Rupinder
Journal name Drug discovery today
Season In Press
Start page 1
End page 9
Total pages 9
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2016-09-28
ISSN 1878-5832
Summary Colorectal cancer (CRC) is a major health burden worldwide. The optimal approach to the diagnosis, management, and treatment of CRC involves multidisciplinary and integrated management practices. The field is rapidly changing because of recent advancements in delineating the molecular basis of tumorigenesis, introduction of targeted therapy, varied patient response to mainstay chemotherapeutics, biological drugs, and the effective combination regimes being used for treatment. Recent meta-analysis studies, which tend to establish few clinically useful predictor biomarkers, identify inconsistent results and limitations of the trials. Therefore, molecular pathological epidemiology discipline initiatives are promising. Here, we provide an overview of the potential of biomarker validation for personalized medicine by focusing largely on metastatic (m)CRC. We also highlight new candidate predictive and prognostic biomarkers.
Language eng
DOI 10.1016/j.drudis.2016.09.022
Field of Research 111502 Clinical Pharmacology and Therapeutics
111299 Oncology and Carcinogenesis not elsewhere classified
111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Elsevier
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Created: Tue, 29 Nov 2016, 12:46:57 EST

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