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New dibutyltin(IV) ladders: syntheses, structures and, optimization and evaluation of cytotoxic potential employing A375 (melanoma) and HCT116 (colon carcinoma) cell lines in vitro

Basu Baul, Tushar S., Dutta, Dhrubajyoti, Duthie, Andrew, Guchhait, Nikhil, Rocha, Bruno G. M., Guedes da Silva, M. Fatima C., Mokhamatam, Raveendra B., Raviprakash, Nune and Manna, Sunil K. 2017, New dibutyltin(IV) ladders: syntheses, structures and, optimization and evaluation of cytotoxic potential employing A375 (melanoma) and HCT116 (colon carcinoma) cell lines in vitro, Journal of inorganic biochemistry, vol. 166, pp. 34-48, doi: 10.1016/j.jinorgbio.2016.10.008.

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Title New dibutyltin(IV) ladders: syntheses, structures and, optimization and evaluation of cytotoxic potential employing A375 (melanoma) and HCT116 (colon carcinoma) cell lines in vitro
Author(s) Basu Baul, Tushar S.
Dutta, Dhrubajyoti
Duthie, Andrew
Guchhait, Nikhil
Rocha, Bruno G. M.
Guedes da Silva, M. Fatima C.
Mokhamatam, Raveendra B.
Raviprakash, Nune
Manna, Sunil K.
Journal name Journal of inorganic biochemistry
Volume number 166
Start page 34
End page 48
Total pages 15
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2017-01
ISSN 1873-3344
0162-0134
Keyword(s) dibutyltin(IV) ladders
structures
melanoma and colon carcinoma cell lines
apoptosis
cytotoxicity
microviscosity
Summary Synthesis and spectroscopic properties of seven new dibutyltin(IV) compounds of 2-{(E)-4-hydroxy-3-[(E)-4-(aryl)iminomethyl]phenyldiazenyl}benzoic acids (L(n)HH'; n=2-8) with general formula {[Bu2Sn(L(n)H)]2O}2 (1-7) are reported. The compounds were characterized by elemental analysis and by UV-Visible, fluorescence, IR, (1)H, (13)C and (119)Sn NMR spectroscopies. Solid state structures of dibutyltin(IV) compounds 1-3, 6 and 7 were accomplished from single crystal X-ray crystallography which reveal the common ladder-type structure with two endo- and two exo-Sn atoms. The redox properties of L(n)HH' (n=2-4, 7 and 8) and their diorganotin(IV) compounds 1-3, 6 and 7 were also investigated by cyclic voltammetry. In general, the dibutyltin(IV) derivatives exhibited significant in vitro cytotoxic potency towards A375 (melanoma) and HCT116 (colon carcinoma) cell lines as determined by several experiments, like Live and Dead assay, MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) cell viability assay, LDH (lactate dehydrogenase), cleavage of caspases and PARP (poly(ADP-ribose)polymerase), and DNA fragmentation. Dibutyltin(IV) compounds increase cell death without cytolysis and decreases membrane fluidity, without interfering with p53. Among the dibutyltin(IV) compounds, compound 6 was found to be the most potent, with an IC50 value of 78nM. A mechanism of action for tumor cell death is proposed.
Language eng
DOI 10.1016/j.jinorgbio.2016.10.008
Field of Research 039904 Organometallic Chemistry
0302 Inorganic Chemistry
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30088619

Document type: Journal Article
Collection: School of Life and Environmental Sciences
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