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Mode of oral iron administration and the amount of iron habitually consumed do not affect iron absorption, systemic iron utilisation or zinc absorption in iron-sufficient infants: a randomised trial

Szymlek-Gay, Ewa A., Domellof, Magnus, Hernell, Olle, Hurrell, Richard F., Lind, Torbjorn, Lonnerdal, Bo, Zeder, Christophe and Egli, Ines M. 2016, Mode of oral iron administration and the amount of iron habitually consumed do not affect iron absorption, systemic iron utilisation or zinc absorption in iron-sufficient infants: a randomised trial, British journal of nutrition, vol. 116, no. 6, pp. 1046-1060, doi: 10.1017/S0007114516003032.

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Title Mode of oral iron administration and the amount of iron habitually consumed do not affect iron absorption, systemic iron utilisation or zinc absorption in iron-sufficient infants: a randomised trial
Author(s) Szymlek-Gay, Ewa A.
Domellof, Magnus
Hernell, Olle
Hurrell, Richard F.
Lind, Torbjorn
Lonnerdal, Bo
Zeder, Christophe
Egli, Ines M.
Journal name British journal of nutrition
Volume number 116
Issue number 6
Start page 1046
End page 1060
Total pages 15
Publisher Cambridge University Press
Place of publication Cambridge, Eng.
Publication date 2016-09
ISSN 0007-1145
1475-2662
Keyword(s) infants
iron absorption
zinc absorption
iron utilisation
infant formula
iron supplements
randomised trials
Summary Different metabolic pathways of supplemental and fortification Fe, or inhibition of Zn absorption by Fe, may explain adverse effects of supplemental Fe in Fe-sufficient infants. We determined whether the mode of oral Fe administration or the amount habitually consumed affects Fe absorption and systemic Fe utilisation in infants, and assessed the effects of these interventions on Zn absorption, Fe and Zn status, and growth. Fe-sufficient 6-month-old infants (n 72) were randomly assigned to receive 6·6 mg Fe/d from a high-Fe formula, 1·3 mg Fe/d from a low-Fe formula or 6·6 mg Fe/d from Fe drops and a formula with no added Fe for 45 d. Fractional Fe absorption, Fe utilisation and fractional Zn absorption were measured with oral (57Fe and 67Zn) and intravenous (58Fe and 70Zn) isotopes. Fe and Zn status, infection and growth were measured. At 45 d, Hb was 6·3 g/l higher in the high-Fe formula group compared with the Fe drops group, whereas serum ferritin was 34 and 35 % higher, respectively, and serum transferrin 0·1 g/l lower in the high-Fe formula and Fe drops groups compared with the low-Fe formula group (all P<0·05). No intervention effects were observed on Fe absorption, Fe utilisation, Zn absorption, other Fe status indices, plasma Zn or growth. We concluded that neither supplemental or fortification Fe nor the amount of Fe habitually consumed altered Fe absorption, Fe utilisation, Zn absorption, Zn status or growth in Fe-sufficient infants. Consumption of low-Fe formula as the only source of Fe was insufficient to maintain Fe stores.
Language eng
DOI 10.1017/S0007114516003032
Field of Research 111103 Nutritional Physiology
111199 Nutrition and Dietetics not elsewhere classified
0702 Animal Production
1111 Nutrition And Dietetics
0908 Food Sciences
Socio Economic Objective 920501 Child Health
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30088742

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