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Curvilinear telomere length dynamics in a squamate reptile

Ujvari, Beata, Biro, Peter A., Charters, Jordan E., Brown, Gregory, Heasman, Kim, Beckmann, Christa and Madsen, Thomas 2016, Curvilinear telomere length dynamics in a squamate reptile, Functional ecology, In Press, pp. 1-7, doi: 10.1111/1365-2435.12764.

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Title Curvilinear telomere length dynamics in a squamate reptile
Author(s) Ujvari, BeataORCID iD for Ujvari, Beata orcid.org/0000-0003-2391-2988
Biro, Peter A.
Charters, Jordan E.
Brown, Gregory
Heasman, Kim
Beckmann, ChristaORCID iD for Beckmann, Christa orcid.org/0000-0002-7904-7228
Madsen, Thomas
Journal name Functional ecology
Season In Press
Start page 1
End page 7
Total pages 7
Publisher Wiley
Place of publication London, Eng.
Publication date 2016-10-17
ISSN 0269-8463
1365-2435
Keyword(s) cellular homeostasis
frillneck lizard
survival
telomerase expression
telomere length dynamics
Summary 1. The lack of consensus concerning the impact of telomere length (TL) dynamics on survival emphasizes the need for additional studies to evaluate the effect of TL on key life-history processes.
2. Using both cross-sectional and longitudinal data, we therefore explored age-specific TL dynamics in a squamate reptile: the frillneck lizard (Chlamydosaurus kingii).
3. Our cross-sectional analyses revealed that young lizards had short TL, TL increased in medium-aged lizards, but TL decreased in older age cohorts, revealing a curvilinear relationship between TL and frillneck lizard age.
4. Neither our cross-sectional nor our longitudinal analyses revealed any association between TL dynamics and lizard survival.
5. We observed a significant positive relationship between TL and telomerase expression (TE), suggesting that TE is a significant determinant of frillneck lizard TL dynamics.
6. Importantly, our longitudinal analyses revealed a positive relationship between initial TL and telomere attrition rate within individual lizards, that is lizards with short initial telomeres were subjected to reduced telomere attrition rates compared to lizards with long initial TL.
7. Our results strongly suggest that TL and TE dynamics in frillneck lizards is not associated with lizard survival but rather reflect an adaptation to maintain TL above a critical minimum length in order to sustain cellular homeostasis.
Language eng
DOI 10.1111/1365-2435.12764
Field of Research 060602 Animal Physiology - Cell
060399 Evolutionary Biology not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2016, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30088746

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Created: Wed, 16 Nov 2016, 13:06:35 EST

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