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Dissecting the function of essential rhoptry genes of the malaria parasite

Ghosh, Sreejoyee 2016, Dissecting the function of essential rhoptry genes of the malaria parasite, PhD. thesis, School of Medicine, Deakin University.

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Title Dissecting the function of essential rhoptry genes of the malaria parasite
Author Ghosh, Sreejoyee
Institution Deakin University
School School of Medicine
Faculty Faculty of Health
Degree type Research doctorate
Degree name PhD.
Thesis advisor De Koning-Ward, TaniaORCID iD for De Koning-Ward, Tania orcid.org/0000-0001-5810-8063
Date submitted 2016-03
Keyword(s) Malaria
Plasmodium
Parasites
Vector control
Microbiology
Summary This thesis explored the role of essential Rhoptry-proteins (RAPs) in parasites that cause malaria. Utilising genetic engineering approaches, this work provides the first formal proof that RAPs are not involved in the invasion of host erythrocytes and instead presents evidence supporting a post-invasion role. This changes the existing notion of RAPs as potential vaccine-candidates to being potential drug-targets.
Language eng
Field of Research 060599 - Microbiology not elsewhere classified 80%
060108 - Protein Trafficking 20%
Socio Economic Objective 970106 - Expanding Knowledge in the Biological Sciences 60% 970111 - Expanding Knowledge in the Medical and Health Sciences 40%
Description of original v, 180 pages : tables, figures, illustrations, some coloured
Restricted until 2017-07-18
Copyright notice ┬ęThe Author. All Rights Reserved
Persistent URL http://hdl.handle.net/10536/DRO/DU:30088998

Document type: Thesis
Collection: Higher degree theses (citation only)
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Created: Wed, 16 Nov 2016, 12:51:39 EST by Deb Gray

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