This thesis explored the role of PTEX88, a putative component of the malaria translocon involved in trafficking parasite proteins into host red blood cells. Reverse genetic approaches were employed to demonstrate PTEX88 plays an auxiliary role in translocon function but has an impact on parasite virulence and immune evasion.
Field of Research
060599 - Microbiology not elsewhere classified 60% 060108 - Protein Trafficking 20% 110803 - Medical Parasitology 20%
Socio Economic Objective
970106 - Expanding Knowledge in the Biological Sciences 80% 970111 - Expanding Knowledge in the Medical and Health Sciences 20%
Description of original
xvi, 185 pages : illustrations, tables, figures, some coloured.
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