Antidepressants and inflammatory bowel disease: a systematic review Mikocka-Walus, Antonina A, Turnbull, Deborah A, Moulding, Nicole T, Wilson, Ian G, Andrews, Jane M and Holtmann, Gerald J 2006, Antidepressants and inflammatory bowel disease: a systematic review, Clinical practice and epidemiology in health, vol. 2, Article number: 24, pp. 1-9, doi: 10.1186/1745-0179-2-24. Attached Files Name Description MIMEType Size Downloads mikockawalus-antidepressantsand-2006.pdf Published version application/pdf 361.84KB 20 Title Antidepressants and inflammatory bowel disease: a systematic review Author(s) Mikocka-Walus, Antonina A orcid.org/0000-0003-4864-3956 Turnbull, Deborah A Moulding, Nicole T Wilson, Ian G Andrews, Jane M Holtmann, Gerald J Journal name Clinical practice and epidemiology in health Volume number 2 Season Article number: 24 Start page 1 End page 9 Total pages 9 Publisher BioMed Central Place of publication London, Eng. Publication date 2006 ISSN 1745-0179 Summary Background A number of studies have suggested a link between the patient's psyche and the course of inflammatory bowel disease (IBD). Although pharmacotherapy with antidepressants has not been widely explored, some investigators have proposed that treating psychological co-morbidities with antidepressants may help to control disease activity. To date a systematic analysis of the available studies assessing the efficacy of antidepressants for the control of somatic symptoms in IBD patients has not been performed. Methods We searched electronic databases, without any language restriction. All relevant papers issued after 1990 were examined. Results 12 relevant publications were identified. All of them referred to non-randomised studies. Antidepressants reported in these publications included paroxetine, bupropion, amitriptyline, phenelzine, and mirtazapine. In 10 articles, paroxetine, bupropion, and phenelzine were suggested to be effective for treating both psychological and somatic symptoms in patients suffering from IBD. Amitriptyline was found ineffective for treating somatic symptoms of IBD. Mirtazapine was not recommended for IBD patients. Conclusion Although most of reviewed papers suggest a beneficial effect of treatment with antidepressants in patients with IBD, due to the lack of reliable data, it is impossible to judge the efficacy of antidepressants in IBD. Properly designed trials are justified and needed based upon the available uncontrolled data. Language eng DOI 10.1186/1745-0179-2-24 Field of Research 110307 Gastroenterology and Hepatology 110319 Psychiatry (incl Psychotherapy) 170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology) 170106 Health, Clinical and Counselling Psychology 1103 Clinical Sciences 1701 Psychology 1117 Public Health And Health Services Socio Economic Objective 920105 Digestive System Disorders HERDC Research category C1.1 Refereed article in a scholarly journal ERA Research output type C Journal article Copyright notice ©2006, The Authors Free to Read? Yes Use Rights Persistent URL http://hdl.handle.net/10536/DRO/DU:30089167 Document type: Journal Article Collections: School of Psychology Open Access Collection Related Links Link Description Connect to published version Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Mon, 21 Nov 2016, 12:51:37 EST Tue, 22 Nov 2016, 04:00:14 EST Tue, 22 Nov 2016, 05:05:36 EST Mon, 06 Feb 2017, 08:49:37 EST Mon, 06 Feb 2017, 08:51:58 EST Mon, 06 Feb 2017, 08:56:05 EST Sat, 13 May 2017, 02:32:39 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 79 times in Scopus Search Google Scholar Access Statistics: 92 Abstract Views, 20 File Downloads  -  Detailed Statistics Created: Mon, 21 Nov 2016, 12:51:37 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.