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Deep brain stimulation mediates neurotrophin signaling in an animal model of antidepressant resistance

REKER, ASHLIE 2016, Deep brain stimulation mediates neurotrophin signaling in an animal model of antidepressant resistance, PhD. thesis, School of Psychology, Deakin University.

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Title Deep brain stimulation mediates neurotrophin signaling in an animal model of antidepressant resistance
Author REKER, ASHLIE
Institution Deakin University
School School of Psychology
Faculty Faculty of Health
Degree type Research doctorate
Degree name PhD.
Thesis advisor Tye, Susannah
McGillivray Jane
Konstantopoulos Nicky
Date submitted 2016-05
Keyword(s) Mental illness
Anti-depressants
Major depressive disorder
Deep brain stimulation
Psychotherapy
Depression
Summary Chronic adrenocorticotropic hormone administration at circadian nadir produces an antidepressant resistance animal model that does not present with an altered plasma corticosterone profile nor changes in hippocampal brain derived neurotrophic factor and its receptor. Acute and chronic infralimbic deep brain stimulation elicited an antidepressant response in this animal model, which appears to be associated with changes in gene and protein expression of key intracellular mediators of neurotrophic factor signaling. Together, these findings stand to make important positive impacts on treatment strategies for one of the most debilitating and prevalent disorders of the modern era and suggest that antidepressant treatment response may involve mechanisms distinct from chronic stress-mediated induction of depression-like behavioral phenotypes.
Language eng
Field of Research 110319 - Psychiatry (incl. Psychotherapy) 100%
Socio Economic Objective 920111 - Nervous System and Disorders 100%
Description of original 263 pages : tables, figures, some coloured, appendices.
Copyright notice ┬ęThe Author. All Rights Reserved
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30089171

Document type: Thesis
Collections: Higher degree theses (full text)
Open Access Collection
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Created: Mon, 21 Nov 2016, 13:19:09 EST by Deb Gray

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.