Chronic adrenocorticotropic hormone administration at circadian nadir produces an antidepressant resistance animal model that does not present with an altered plasma corticosterone profile nor changes in hippocampal brain derived neurotrophic factor and its receptor. Acute and chronic infralimbic deep brain stimulation elicited an antidepressant response in this animal model, which appears to be associated with changes in gene and protein expression of key intracellular mediators of neurotrophic factor signaling. Together, these findings stand to make important positive impacts on treatment strategies for one of the most debilitating and prevalent disorders of the modern era and suggest that antidepressant treatment response may involve mechanisms distinct from chronic stress-mediated induction of depression-like behavioral phenotypes.
Field of Research
110319 - Psychiatry (incl. Psychotherapy) 100%
Socio Economic Objective
920111 - Nervous System and Disorders 100%
Description of original
263 pages : tables, figures, some coloured, appendices.
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