Can antidepressants influence the course of inflammatory bowel disease? The current state of research

Mikocka-Walus, Antonina, Clarke, David and Gibson, Peter R. 2009, Can antidepressants influence the course of inflammatory bowel disease? The current state of research, European gastroenterology & hepatology review, vol. 5, no. 1, pp. 48-53.

Attached Files
Name Description MIMEType Size Downloads

Title Can antidepressants influence the course of inflammatory bowel disease? The current state of research
Author(s) Mikocka-Walus, AntoninaORCID iD for Mikocka-Walus, Antonina
Clarke, David
Gibson, Peter R.
Journal name European gastroenterology & hepatology review
Volume number 5
Issue number 1
Start page 48
End page 53
Total pages 6
Publisher Touch Media
Place of publication London, Eng.
Publication date 2009
ISSN 1758-3799
Keyword(s) inflammatory bowel disease
Summary A previous systematic review conducted in 2006 indicated that antidepressants may have the potential to improve the course of inflammatory bowel disease (IBD). The current study is an update of this review, aiming to identify and summarise available data on the effect of antidepressants on IBD activity published between 2006 and 2009. Electronic databases were searched to identify all relevant publications issued between 2006 and 2009 in English. Four studies met the inclusion criteria, three randomised controlled trials (RCTs) and one qualitative interview study. Six other papers with relevance to the subject that did not meet inclusion cirteria were also indentified. Desipramine was found to reduce vulnerability to colitis and to improve all examined inflammatory markers in the three animal RCTs, fluoxetine was found to protect against colitis in one RCT. Overall, the studies suggest a positive impact of antidepressants on inflammation in IBD. However, good-quality human data are lacking and more RCTs are needed.
Language eng
Field of Research 110307 Gastroenterology and Hepatology
110319 Psychiatry (incl Psychotherapy)
Socio Economic Objective 920105 Digestive System Disorders
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2009, Touch Briefings
Persistent URL

Document type: Journal Article
Collections: Faculty of Health
School of Psychology
Connect to link resolver
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in TR Web of Science
Scopus Citation Count Cited 0 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 224 Abstract Views, 1 File Downloads  -  Detailed Statistics
Created: Mon, 21 Nov 2016, 13:57:18 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact