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A systematic review and secondary data analysis of the interactions between the serotonin transporter 5-HTTLPR polymorphism and environmental and psychological factors in eating disorders

Rozenblat, Vanja, Ong, Deborah, Fuller-Tyszkiewicz, Matthew, Akkermann, Kirsti, Collier, David, Engels, Rutger CME, Fernandez-Aranda, Fernando, Harro, Jaanus, Homberg, Judith R, Karwautz, Andreas, Kiive, Evelyn, Klump, Kelly L, Larson, Christine L, Racine, Sarah E, Richardson, Jodie, Steiger, Howard, Stoltenberg, Scott F, van Strien, Tatjana, Wagner, Gudrun, Treasure, Janet and Krug, Isabel 2017, A systematic review and secondary data analysis of the interactions between the serotonin transporter 5-HTTLPR polymorphism and environmental and psychological factors in eating disorders, Journal of psychiatric research, vol. 84, pp. 62-72, doi: 10.1016/j.jpsychires.2016.09.023.

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Title A systematic review and secondary data analysis of the interactions between the serotonin transporter 5-HTTLPR polymorphism and environmental and psychological factors in eating disorders
Author(s) Rozenblat, Vanja
Ong, Deborah
Fuller-Tyszkiewicz, MatthewORCID iD for Fuller-Tyszkiewicz, Matthew orcid.org/0000-0003-1145-6057
Akkermann, Kirsti
Collier, David
Engels, Rutger CME
Fernandez-Aranda, Fernando
Harro, Jaanus
Homberg, Judith R
Karwautz, Andreas
Kiive, Evelyn
Klump, Kelly L
Larson, Christine L
Racine, Sarah E
Richardson, Jodie
Steiger, Howard
Stoltenberg, Scott F
van Strien, Tatjana
Wagner, Gudrun
Treasure, Janet
Krug, Isabel
Journal name Journal of psychiatric research
Volume number 84
Start page 62
End page 72
Total pages 11
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2017-01
ISSN 0022-3956
1879-1379
Keyword(s) 5-HTTLPR
Bulimia nervosa
Eating disorders
Gene-environment interaction
Meta-analysis
Systematic review
Science & Technology
Life Sciences & Biomedicine
Psychiatry
Life-stress
Differential susceptability
Bulimic syndromes
Childhood traumas
Sexual-abuse
Risk-factors
Gene
Depression
Metaanalysis
Association
Summary OBJECTIVES: To summarize and synthesize the growing gene x environment (GxE) research investigating the promoter region of the serotonin transporter gene (5-HTTLPR) in the eating disorders (ED) field, and overcome the common limitation of low sample size, by undertaking a systematic review followed by a secondary data meta-analysis of studies identified by the review. METHOD: A systematic review of articles using PsycINFO, PubMed, and EMBASE was undertaken to identify studies investigating the interaction between 5-HTTLPR and an environmental or psychological factor, with an ED-related outcome variable. Seven studies were identified by the systematic review, with complete data sets of five community (n = 1750, 64.5% female) and two clinical (n = 426, 100% female) samples combined to perform four secondary-data analyses: 5-HTTLPR x Traumatic Life Events to predict ED status (n = 909), 5-HTTLPR x Sexual and Physical Abuse to predict bulimic symptoms (n = 1097), 5-HTTLPR x Depression to predict bulimic symptoms (n = 1256), and 5-HTTLPR x Impulsiveness to predict disordered eating (n = 1149). RESULTS: Under a multiplicative model, the low function (s) allele of 5-HTTLPR interacted with traumatic life events and experiencing both sexual and physical abuse (but not only one) to predict increased likelihood of an ED and bulimic symptoms, respectively. However, under an additive model there was also an interaction between sexual and physical abuse considered independently and 5-HTTLPR, and no interaction with traumatic life events. No other GxE interactions were significant. CONCLUSION: Early promising results should be followed-up with continued cross-institutional collaboration in order to achieve the large sample sizes necessary for genetic research.
Language eng
DOI 10.1016/j.jpsychires.2016.09.023
Field of Research 170106 Health, Clinical and Counselling Psychology
11 Medical And Health Sciences
17 Psychology And Cognitive Sciences
Socio Economic Objective 920401 Behaviour and Health
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Elsevier Ltd.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30089266

Document type: Journal Article
Collections: Faculty of Health
School of Psychology
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