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Perinatal microbial exposure may influence aortic intima-media thickness in early infancy

McCloskey, Kate, Vuillermin, Peter, Carlin, John B., Cheung, Michael, Skilton, Michael R., Tang, Mimi L. K., Allen, Katie, Gilbert, Gwendolyn L., Ranganathan, Sarath, Collier, Fiona, Dwyer, Terence, Ponsonby, Anne-Louise and Burgner, David 2016, Perinatal microbial exposure may influence aortic intima-media thickness in early infancy, International journal of epidemiology, doi: 10.1093/ije/dyw042.

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Title Perinatal microbial exposure may influence aortic intima-media thickness in early infancy
Author(s) McCloskey, Kate
Vuillermin, Peter
Carlin, John B.
Cheung, Michael
Skilton, Michael R.
Tang, Mimi L. K.
Allen, Katie
Gilbert, Gwendolyn L.
Ranganathan, Sarath
Collier, Fiona
Dwyer, Terence
Ponsonby, Anne-Louise
Burgner, David
Journal name International journal of epidemiology
Total pages 10
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2016-04-08
ISSN 0300-5771
Keyword(s) cardiovascular
intima-media thickness
BIS Investigator Group
Summary BACKGROUND: The maternal and infant microbiome may influence infant cardiovascular risk through immune programming. The maternal vagino-enteric microbiome is often sampled for group B streptococcus (GBS) colonization during pregnancy. Our aim was to investigate the association between maternal GBS colonization, intrapartum antibiotics, antenatal pet exposure and infant aortic intima-media thickness (aIMT), an intermediate vascular phenotype, and whether this association varied by mode of delivery.
METHODS: The Barwon Infant Study is a population-derived pre-birth cohort. Perinatal data were collected on participants. Women were tested for vagino-enteric group B streptococcus (GBS) colonization during third trimester. Six-week infant aIMT was measured by trans-abdominal ultrasound. Adjustment for confounders included maternal age, pre-pregnancy body mass index (BMI), smoking, socioeconomic status, gestational diabetes, length of gestation, infant sex, birthweight and aortic internal diameter.
RESULTS: Data were available on 835 mother-infant pairs. Of these, 574 (69%) women delivered vaginally; of those, 129 (22%) were GBS-colonized; and of these women, 111 (86%) received prophylactic intrapartum antibiotics. An association between maternal GBS colonization and infant aIMT was observed among those delivered vaginally (β = 19.5 µm, 95% CI 9.5, 29.4;P < 0.0001) but not by Caesarean section (Pfor interaction = 0.02). A similar pattern was seen for intrapartum antibiotics. There was a negative association between antenatal pet exposure and aIMT observed in those delivered vaginally.
CONCLUSION: Maternal GBS colonization and intrapartum antibiotics were associated with increased infant aIMT in those delivered vaginally, whereas antenatal pet exposure was associated with decreased aIMT. These data suggest that differences in early life microbial experience may contribute to an increased cardiovascular risk.
Notes In press
Language eng
DOI 10.1093/ije/dyw042
Field of Research 110299 Cardiorespiratory Medicine and Haematology not elsewhere classified
0104 Statistics
1117 Public Health And Health Services
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, The Authors
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Document type: Journal Article
Collection: School of Medicine
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