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Novel therapeutics for complex diseases from genome-wide association data

GROVER, MANI 2016, Novel therapeutics for complex diseases from genome-wide association data, PhD. thesis, School of Medicine, Deakin University.

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Title Novel therapeutics for complex diseases from genome-wide association data
Author GROVER, MANI
Institution Deakin University
School School of Medicine
Faculty Faculty of Health
Degree type Research doctorate
Degree name PhD.
Thesis advisor Wouters, Merridee
Crowley Tamsyn
Sherman, CraigORCID iD for Sherman, Craig orcid.org/0000-0003-2099-0462
Date submitted 2016-10
Keyword(s) Genetics
pharmacology
Therapeutic drugs
Diseases
Gene therapy
Databases
Summary The development of novel therapies is essential to lower the burden of complex diseases. The purpose of this study is to identify novel therapeutics for complex diseases using bioinformatic methods. Bioinformatic tools such as candidate gene prediction tools allow identification of disease genes by identifying the potential candidate genes linked to genetic markers of the disease. Candidate gene prediction tools can only identify candidates for further research, and do not identify disease genes directly. Integration of drug-target datasets with candidate gene data-sets can identify novel potential therapeutics suitable for repositioning in clinical trials. Drug repositioning can save valuable time and money spent in therapeutic development of complex diseases.
Language eng
Field of Research 060102 - Bioinformatics 60%
060499 - Genetics not elsewhere classified 40%
Socio Economic Objective 920110 - Inherited Diseases (incl. Gene Therapy) 90%; 890202 - Application Tools and System Utilities 10%
Description of original xi, 133 pages : figures, tables, some coloured, appendices
Copyright notice ┬ęThe Author. All Rights Reserved
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30089382

Document type: Thesis
Collections: Higher degree theses (full text)
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Created: Fri, 25 Nov 2016, 12:31:56 EST by Deb Gray

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.