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Plasma 25-hydroxyvitamin D level is related to protein signaling involved in glucose homeostasis in a tissue-specific manner

Parker, Lewan, Levinger, Itamar, Mousa, Aya, Howlett, Kirsten and de Courten, Barbora 2016, Plasma 25-hydroxyvitamin D level is related to protein signaling involved in glucose homeostasis in a tissue-specific manner, Nutrients, vol. 8, no. 10, Article Number : 631, pp. 1-9, doi: 10.3390/nu8100631.

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Title Plasma 25-hydroxyvitamin D level is related to protein signaling involved in glucose homeostasis in a tissue-specific manner
Author(s) Parker, Lewan
Levinger, Itamar
Mousa, Aya
Howlett, KirstenORCID iD for Howlett, Kirsten orcid.org/0000-0002-8571-4867
de Courten, Barbora
Journal name Nutrients
Volume number 8
Issue number 10
Season Article Number : 631
Start page 1
End page 9
Total pages 9
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2016-10
ISSN 2072-6643
Keyword(s) diabetes
glucose homeostasis
insulin resistance
insulin signaling
vitamin D
25-hydroxyvitamin D
Science & Technology
Life Sciences & Biomedicine
Nutrition & Dietetics
VITAMIN-D DEFICIENCY
PHOSPHATIDYLINOSITOL 3-KINASE ACTIVITY
RANDOMIZED CONTROLLED-TRIAL
PLACEBO-CONTROLLED TRIAL
HUMAN SKELETAL-MUSCLE
MIDDLE-AGED MEN
INSULIN-RESISTANCE
DIABETES-MELLITUS
GLUT-4 PHOSPHORYLATION
D SUPPLEMENTATION
Summary Vitamin D has been suggested to play a role in glucose metabolism. However, previous findings are contradictory and mechanistic pathways remain unclear. We examined the relationship between plasma 25-hydroxyvitamin D (25(OH)D), insulin sensitivity, and insulin signaling in skeletal muscle and adipose tissue. Seventeen healthy adults (Body mass index: 26 ± 4; Age: 30 ± 12 years) underwent a hyperinsulinemic-euglycemic clamp, and resting skeletal muscle and adipose tissue biopsies. In this cohort, the plasma 25(OH)D concentration was not associated with insulin sensitivity (r = 0.19, p = 0.56). However, higher plasma 25(OH)D concentrations correlated with lower phosphorylation of glycogen synthase kinase-3 (GSK-3) αSer21 and βSer9 in skeletal muscle (r = −0.66, p = 0.015 and r = −0.53, p = 0.06, respectively) and higher GSK-3 αSer21 and βSer9 phosphorylation in adipose tissue (r = 0.82, p < 0.01 and r = 0.62, p = 0.042, respectively). Furthermore, higher plasma 25(OH)D concentrations were associated with greater phosphorylation of both protein kinase-B (AktSer473) (r = 0.78, p < 0.001) and insulin receptor substrate-1 (IRS-1Ser312) (r = 0.71, p = 0.01) in adipose tissue. No associations were found between plasma 25(OH)D concentration and IRS-1Tyr612 phosphorylation in skeletal muscle and adipose tissue. The divergent findings between muscle and adipose tissue with regard to the association between 25(OH)D and insulin signaling proteins may suggest a tissue-specific interaction with varying effects on glucose homeostasis. Further research is required to elucidate the physiological relevance of 25(OH)D in each tissue.
Language eng
DOI 10.3390/nu8100631
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
1111 Nutrition And Dietetics
Socio Economic Objective 920104 Diabetes
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30089457

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.