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Measures to predict the individual variability of corticospinal responses following transcranial direct current stimulation

Nuzum, Nathan D., Hendy, Ashlee M., Russell, Aaron P. and Teo, Wei-Peng 2016, Measures to predict the individual variability of corticospinal responses following transcranial direct current stimulation, Frontiers in human neuroscience, vol. 10, Article number: 487, pp. 1-12, doi: 10.3389/fnhum.2016.00487.

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Title Measures to predict the individual variability of corticospinal responses following transcranial direct current stimulation
Author(s) Nuzum, Nathan D.
Hendy, Ashlee M.
Russell, Aaron P.ORCID iD for Russell, Aaron P. orcid.org/0000-0002-7323-9501
Teo, Wei-PengORCID iD for Teo, Wei-Peng orcid.org/0000-0003-3929-9778
Journal name Frontiers in human neuroscience
Volume number 10
Season Article number: 487
Start page 1
End page 12
Total pages 12
Publisher Frontiers Research Foundation
Place of publication Lausanne, Switzerland
Publication date 2016-10-06
ISSN 1662-5161
Keyword(s) anodal tDCS
transcranial magnetic stimulation
latency
I-waves
short intracortical facilitation
Summary Individual responses to transcranial direct current stimulation (tDCS) are varied and therefore potentially limit its application. There is evidence that this variability is related to the contributions of Indirect waves (I-waves) recruited in the cortex. The latency of motor-evoked potentials (MEPs) can be measured through transcranial magnetic stimulation (TMS), allowing an individual's responsiveness to tDCS to be determined. However, this single-pulse method requires several different orientations of the TMS coil, potentially affecting its reliability. Instead, we propose a paired-pulse TMS paradigm targeting I-waves as an alternative method. This method uses one orientation that reduces inter- and intra-trial variability. It was hypothesized that the paired-pulse method would correlate more highly to tDCS responses than the single-pulse method. In a randomized, double blinded, cross-over design, 30 healthy participants completed two sessions, receiving 20 min of either anodal (2 mA) or sham tDCS. TMS was used to quantify Short interval intracortical facilitation (SICF) at Inter stimulus intervals (ISIs) of 1.5, 3.5 and 4.5 ms. Latency was determined in the posterior-anterior (PA), anterior-posterior (AP) and latero-medial (LM) coil orientations. The relationship between latency, SICF measures and the change in suprathreshold MEP amplitude size following tDCS were determined with Pearson's correlations. TMS measures, SICI and SICF were also used to determine responses to Anodal-tDCS (a-tDCS). Neither of the latency differences nor the SICF measures correlated to the change in MEP amplitude from pre-post tDCS (all P > 0.05). Overall, there was no significant response to tDCS in this cohort. This study highlights the need for testing the effects of various tDCS protocols on the different I-waves. Further research into SICF and whether it is a viable measure of I-wave facilitation is warranted.
Language eng
DOI 10.3389/fnhum.2016.00487
Field of Research 110999 Neurosciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30089516

Document type: Journal Article
Collections: School of Exercise and Nutrition Sciences
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.