Evolutionary ecology of organs: a missing link in cancer development? Thomas, Frédéric, Nesse, Randolph M, Gatenby, Robert, Gidoin, Cindy, Renaud, François, Roche, Benjamin and Ujvari, Beata 2016, Evolutionary ecology of organs: a missing link in cancer development?, Trends in cancer, vol. 2, no. 8, pp. 409-415, doi: 10.1016/j.trecan.2016.06.009. Attached Files Name Description MIMEType Size Downloads Title Evolutionary ecology of organs: a missing link in cancer development? Author(s) Thomas, Frédéric Nesse, Randolph M Gatenby, Robert Gidoin, Cindy Renaud, François Roche, Benjamin Ujvari, Beata orcid.org/0000-0003-2391-2988 Journal name Trends in cancer Volume number 2 Issue number 8 Start page 409 End page 415 Total pages 7 Publisher Elsevier Place of publication Amsterdam, The Netherlands Publication date 2016-08 ISSN 2405-8033 Keyword(s) cancer ecosystems organs malignant transformation intrinsic causes extrinsic causes ecology organ ecology Summary There is striking variation in the incidence of cancer in human organs. Malignant tumors are common in the colon and breast but rare in the heart and small bowel. The uterus frequently develops benign fibroid tumors but uterine cancers are relatively rare. The organ-specific difference in cancer prevalence has been explained primarily by the relative roles of intrinsic and extrinsic risk factors. In this opinion article, we propose also considering organs as distinct but connected ecosystems whose different vulnerabilities to malignant transformation may be partially explained by how essential each organ is for survival through the age of reproduction. We present and discuss some of the basic concepts and assumptions of this perspective on evolutionary medicine. Language eng DOI 10.1016/j.trecan.2016.06.009 Field of Research 111299 Oncology and Carcinogenesis not elsewhere classified 119999 Medical and Health Sciences not elsewhere classified Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences HERDC Research category C1 Refereed article in a scholarly journal ERA Research output type C Journal article Copyright notice ©2016, Elsevier Inc. Persistent URL http://hdl.handle.net/10536/DRO/DU:30089540 Document type: Journal Article Collection: School of Life and Environmental Sciences Related Links Link Description Connect to published version Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Mon, 28 Nov 2016, 14:53:08 EST Thu, 06 Apr 2017, 12:45:18 EST Fri, 07 Apr 2017, 05:00:55 EST Fri, 07 Apr 2017, 06:07:27 EST Wed, 14 Jun 2017, 14:57:28 EST Wed, 14 Jun 2017, 15:00:02 EST Thu, 15 Jun 2017, 08:14:37 EST Sat, 16 Jun 2018, 02:31:50 EST Filtered Full Citation counts:   Cited 8 times in TR Web of Science Cited 7 times in Scopus Search Google Scholar Access Statistics: 111 Abstract Views, 4 File Downloads  -  Detailed Statistics Created: Thu, 06 Apr 2017, 12:45:18 EST

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