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Effect of resistance training on microvascular density and eNOS content in skeletal muscle of sedentary men

Cocks, Mathew, Shaw, Christopher S., Shepherd, Sam O., Fisher, James P., Ranasinghe, Aaron M., Barker, Thomas A., Tipton, Kevin D. and Wagenmakers, Anton J. M. 2014, Effect of resistance training on microvascular density and eNOS content in skeletal muscle of sedentary men, Microcirculation, vol. 21, no. 8, pp. 738-746, doi: 10.1111/micc.12155.

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Title Effect of resistance training on microvascular density and eNOS content in skeletal muscle of sedentary men
Author(s) Cocks, Mathew
Shaw, Christopher S.ORCID iD for Shaw, Christopher S. orcid.org/0000-0003-1499-0220
Shepherd, Sam O.
Fisher, James P.
Ranasinghe, Aaron M.
Barker, Thomas A.
Tipton, Kevin D.
Wagenmakers, Anton J. M.
Journal name Microcirculation
Volume number 21
Issue number 8
Start page 738
End page 746
Total pages 9
Publisher Wiley-Blackwell
Place of publication Chichester, Eng.
Publication date 2014-11
ISSN 1549-8719
Keyword(s) NAD(P)Hoxidase
insulin sensitivity
muscle microvascular endothelial function
nitric oxide
Adult
Humans
Male
Microcirculation
Muscle, Skeletal
Nitric Oxide Synthase Type III
Phosphorylation
Physical Fitness
Summary OBJECTIVE: The effects of RT on muscle mass, strength, and insulin sensitivity are well established, but the underlying mechanisms are only partially understood. The main aim of this study was to investigate whether RT induces changes in endothelial enzymes of the muscle microvasculature, which would increase NO bioavailability and could contribute to improved insulin sensitivity. METHODS: Eight previously sedentary males (age 20 ± 0.4 years, BMI 24.5 ± 0.9 kg/m(2) ) completed six weeks of RT 3x/week. Muscle biopsies were taken from the m. vastus lateralis and microvascular density; and endothelial-specific eNOS content, eNOS Ser(1177) phosphorylation, and NOX2 content were assessed pre- and post-RT using quantitative immunofluorescence microscopy. Whole-body insulin sensitivity (measured as Matsuda Index), microvascular Kf (functional measure of the total available endothelial surface area), and arterial stiffness (AIx, central, and pPWV) were also measured. RESULTS: Measures of microvascular density, microvascular Kf , microvascular eNOS content, basal eNOS phosphorylation, and endothelial NOX2 content did not change from pre-RT to post-RT. RT increased insulin sensitivity (p < 0.05) and reduced resting blood pressure and AIx (p < 0.05), but did not change central or pPWV. CONCLUSIONS: RT did not change any measure of muscle microvascular structure or function.
Language eng
DOI 10.1111/micc.12155
Field of Research 110399 Clinical Sciences not elsewhere classified
11 Medical And Health Sciences
Socio Economic Objective 920116 Skeletal System and Disorders (incl. Arthritis)
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, John Wiley & Sons
Persistent URL http://hdl.handle.net/10536/DRO/DU:30089563

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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