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Beneficial effects of resistance exercise on glycemic control are not further improved by protein ingestion

Breen, Leigh, Philp, Andrew, Shaw, Christopher S., Jeukendrup, Asker E., Baar, Keith and Tipton, Kevin D. 2011, Beneficial effects of resistance exercise on glycemic control are not further improved by protein ingestion, PLoS one, vol. 6, no. 6, pp. 1-13, doi: 10.1371/journal.pone.0020613.

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Title Beneficial effects of resistance exercise on glycemic control are not further improved by protein ingestion
Author(s) Breen, Leigh
Philp, Andrew
Shaw, Christopher S.ORCID iD for Shaw, Christopher S. orcid.org/0000-0003-1499-0220
Jeukendrup, Asker E.
Baar, Keith
Tipton, Kevin D.
Journal name PLoS one
Volume number 6
Issue number 6
Article ID e20613
Start page 1
End page 13
Total pages 13
Publisher Public Library of Science
Place of publication San Francisco, Calif.
Publication date 2011-06
ISSN 1932-6203
Keyword(s) insulin
biopsy
phosphorylation
glucose
blood plasma
exercise
glycogens
muscle proteins
Blood Glucose
Blotting, Western
Dietary Proteins
Glucose Tolerance Test
Humans
Immunoprecipitation
Male
Muscles
Proteins
Summary PURPOSE: To investigate the mechanisms underpinning modifications in glucose homeostasis and insulin sensitivity 24 h after a bout of resistance exercise (RE) with or without protein ingestion.

METHODS: Twenty-four healthy males were assigned to a control (CON; n = 8), exercise (EX; n = 8) or exercise plus protein condition (EX+PRO; n = 8). Muscle biopsy and blood samples were obtained at rest for all groups and immediately post-RE (75% 1RM, 8×10 repetitions of leg-press and extension exercise) for EX and EX+PRO only. At 24 h post-RE (or post-resting biopsy for CON), a further muscle biopsy was obtained. Participants then consumed an oral glucose load (OGTT) containing 2 g of [U-¹³C] glucose during an infusion of 6, 6-[²H₂] glucose. Blood samples were obtained every 10 min for 2 h to determine glucose kinetics. EX+PRO ingested an additional 25 g of intact whey protein with the OGTT. A final biopsy sample was obtained at the end of the OGTT.

RESULTS: Fasted plasma glucose and insulin were similar for all groups and were not different immediately post- and 24 h post-RE. Following RE, muscle glycogen was 26±8 and 19±6% lower in EX and EX+PRO, respectively. During OGTT, plasma glucose AUC was lower for EX and EX+PRO (75.1±2.7 and 75.3±2.8 mmol·L⁻¹∶120 min, respectively) compared with CON (90.6±4.1 mmol·L⁻¹∶120 min). Plasma insulin response was 13±2 and 21±4% lower for EX and CON, respectively, compared with EX+PRO. Glucose disappearance from the circulation was ∼12% greater in EX and EX+PRO compared with CON. Basal 24 h post-RE and insulin-stimulated PAS-AS160/TBC1D4 phosphorylation was greater for EX and EX+PRO.

CONCLUSIONS: Prior RE improves glycemic control and insulin sensitivity through an increase in the rate at which glucose is disposed from the circulation. However, co-ingesting protein during a high-glucose load does not augment this response at 24 h post-exercise in healthy, insulin-sensitive individuals.
Language eng
DOI 10.1371/journal.pone.0020613
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
MD Multidisciplinary
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2011, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30089565

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.