Long bone robustness during growth: a cross-sectional pQCT examination of children and young adults aged 5-29 years

Rantalainen, Timo, Weeks, Benjamin K., Nogueira, Rossana C. and Beck, Belinda R. 2016, Long bone robustness during growth: a cross-sectional pQCT examination of children and young adults aged 5-29 years, Bone, vol. 93, pp. 71-78, doi: 10.1016/j.bone.2016.09.015.

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Title Long bone robustness during growth: a cross-sectional pQCT examination of children and young adults aged 5-29 years
Author(s) Rantalainen, TimoORCID iD for Rantalainen, Timo orcid.org/0000-0001-6977-4782
Weeks, Benjamin K.
Nogueira, Rossana C.
Beck, Belinda R.
Journal name Bone
Volume number 93
Start page 71
End page 78
Total pages 8
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2016-12
ISSN 1873-2763
Keyword(s) BPAQ
Bone QCT
Growth
Morphology
Ontogeny
Puberty
Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
STRESS-FRACTURES
PHYSICAL-ACTIVITY
SEXUAL-DIMORPHISM
STRENGTH INDEXES
MINERAL DENSITY
20-MONTH PQCT
RISK-FACTOR
GEOMETRY
INJURIES
MATURITY
Summary Skeletal robustness (cross-section size relative to length) is associated with stress fractures in adults, and appears to explain the high incidence of distal radius fractures in adolescents. However, little is known about the ontogeny of long bone robustness during the first three decades of life. Therefore, we explored the ontogeny of tibial, fibular, ulnar and radial robustness in a cross-sectional sample of 5 to 29year-old volunteers of both sexes. Peripheral quantitative computed tomography (pQCT) was used to evaluate cross-sections of the leg (4%, 14%, 38% and 66%), and forearm (4%, and 66%) in N=432 individuals. Robustness was evaluated as the total bone area divided by bone length. Differences between age-groups, sexes, and age-group×sex interactions were evaluated with ANOVA with Tukey's post hocs where appropriate. Most bone sites exhibited more robust bones in men than women (P<0.001 to 0.02), and in older age-groups than younger (P<0.001). Sex×age-group interaction was observed at the 66% and 38% tibia sites with robustness increasing more with age in men than in women (P=0.006 to 0.042). Post-hoc analyses indicated no sex differences prior to 13years-of-age, and notable exceptions to increasing robustness with age at the 4% radial and 66% tibial sites, which exhibited reduced robustness in age groups close to peak height velocity. In conclusion, the present results suggest that very little sexual dimorphism in long bone robustness exists prior to puberty, and that divergence occurs primarily after cessation of longitudinal growth. A period of relative diaphyseal slenderness was identified at age-groups coinciding with the adolescent growth spurt, which may be related to the relatively high incidence of frank and stress fracture in adolescents.
Language eng
DOI 10.1016/j.bone.2016.09.015
Field of Research 110399 Clinical Sciences not elsewhere classified
11 Medical And Health Sciences
06 Biological Sciences
09 Engineering
Socio Economic Objective 920501 Child Health
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30089638

Document type: Journal Article
Collections: Faculty of Health
School of Exercise and Nutrition Sciences
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