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Effects of a progressive aquatic resistance exercise program on the biochemical composition and morphology of cartilage in women with mild knee osteoarthritis: protocol for a randomised controlled trial

Waller, Benjamin, Munukka, Matti, Multanen, Juhani, Rantalainen, Timo, Pöyhönen, Tapani, Nieminen, Miika T, Kiviranta, Ilkka, Kautiainen, Hannu, Selänne, Harri, Dekker, Joost, Sipilä, Sarianna, Kujala, Urho M, Häkkinen, Arja and Heinonen, Ari 2013, Effects of a progressive aquatic resistance exercise program on the biochemical composition and morphology of cartilage in women with mild knee osteoarthritis: protocol for a randomised controlled trial, BMC musculoskeletal disorders, vol. 14, pp. 1-14, doi: 10.1186/1471-2474-14-82.

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Title Effects of a progressive aquatic resistance exercise program on the biochemical composition and morphology of cartilage in women with mild knee osteoarthritis: protocol for a randomised controlled trial
Author(s) Waller, Benjamin
Munukka, Matti
Multanen, Juhani
Rantalainen, TimoORCID iD for Rantalainen, Timo orcid.org/0000-0001-6977-4782
Pöyhönen, Tapani
Nieminen, Miika T
Kiviranta, Ilkka
Kautiainen, Hannu
Selänne, Harri
Dekker, Joost
Sipilä, Sarianna
Kujala, Urho M
Häkkinen, Arja
Heinonen, Ari
Journal name BMC musculoskeletal disorders
Volume number 14
Article ID 82
Start page 1
End page 14
Total pages 14
Publisher BioMed Central
Place of publication London, Eng.
Publication date 2013
ISSN 1471-2474
Keyword(s) osteoarthritis
quantitative MRI
T2 relaxation time
dGEMRIC
bone
aquatic exercise
Absorptiometry, Photon
Aged
Biomechanical Phenomena
Body Composition
Cartilage, Articular
Contrast Media
Female
Finland
Humans
Immersion
Knee Joint
Magnetic Resonance Imaging
Middle Aged
Osteoarthritis, Knee
Pain Measurement
Physical Examination
Postmenopause
Predictive Value of Tests
Research Design
Resistance Training
Severity of Illness Index
Surveys and Questionnaires
Swimming Pools
Time Factors
Tomography, X-Ray Computed
Treatment Outcome
Summary BACKGROUND: Symptoms associated with osteoarthritis of the knee result in decreased function, loss of working capacity and extensive social and medical costs. There is a need to investigate and develop effective interventions to minimise the impact of and even prevent the progression of osteoarthritis. Aquatic exercise has been shown to be effective at reducing the impact of osteoarthritis. The purpose of this article is to describe the rationale, design and intervention of a study investigating the effect of an aquatic resistance exercise intervention on cartilage in postmenopausal women with mild knee osteoarthritis.

METHODS: A minimum of 80 volunteers who meet the inclusion criteria will be recruited from the local population through newspaper advertisements. Following initial assessment volunteers will be randomised into two groups. The intervention group will participate in a progressive aquatic resistance exercise program of 1-hour duration 3 times a week for four months. The control group will be asked to maintain normal care during this period. Primary outcome measure for this study is the biochemical composition of knee cartilage measured using quantitative magnetic resonance imaging; T2 relaxation time and delayed gadolinium-enhanced magnetic resonance imaging techniques. In addition, knee cartilage morphology as regional cartilage thickness will be studied. Secondary outcomes include measures of body composition and bone traits using dual energy x-ray absorptiometry and peripheral quantitative computed tomography, pain, function using questionnaires and physical performance tests and quality of life. Measurements will be performed at baseline, after the 4-month intervention period and at one year follow up.

DISCUSSION: This randomised controlled trial will investigate the effect a progressive aquatic resistance exercise program has on the biochemical composition of cartilage in post-menopausal women with mild knee osteoarthritis. This is the first study to investigate what impact aquatic exercise has on human articular cartilage. In addition it will investigate the effect aquatic exercise has on physical function, pain, bone and body composition and quality of life. The results of this study will help optimise the prescription of aquatic exercise to persons with mild knee osteoarthritis.
Language eng
DOI 10.1186/1471-2474-14-82
Field of Research 110399 Clinical Sciences not elsewhere classified
1103 Clinical Sciences
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2013, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30089640

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.