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Striated muscle activator of Rho signalling (STARS) is reduced in ageing human skeletal muscle and targeted by miR-628-5p

Russell, A.P., Wallace, M.A., Kalanon, M., Zacharewicz, E., Della Gatta, P.A., Garnham, A. and Lamon, S 2016, Striated muscle activator of Rho signalling (STARS) is reduced in ageing human skeletal muscle and targeted by miR-628-5p, Acta physiologica, Early view, pp. 1-12, doi: 10.1111/apha.12819.

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Title Striated muscle activator of Rho signalling (STARS) is reduced in ageing human skeletal muscle and targeted by miR-628-5p
Author(s) Russell, A.P.
Wallace, M.A.
Kalanon, M.
Zacharewicz, E.
Della Gatta, P.A.ORCID iD for Della Gatta, P.A. orcid.org/0000-0003-2231-8370
Garnham, A.
Lamon, SORCID iD for Lamon, S orcid.org/0000-0002-3271-6551
Journal name Acta physiologica
Season Early view
Start page 1
End page 12
Total pages 12
Publisher Wiley
Place of publication London, Eng.
Publication date 2016-10-14
ISSN 1748-1716
Keyword(s) ageing
exercise
microRNA
skeletal muscle
striated muscle activator of Rho signalling
Summary AIM: The striated muscle activator of Rho signalling (STARS) is a muscle-specific actin-binding protein. The STARS signalling pathway is activated by resistance exercise and is anticipated to play a role in signal mechanotransduction. Animal studies have reported a negative regulation of STARS signalling with age, but such regulation has not been investigated in humans.

METHODS: Ten young (18-30 years) and 10 older (60-75 years) subjects completed an acute bout of resistance exercise. Gene and protein expression of members of the STARS signalling pathway and miRNA expression of a subset of miRNAs, predicted or known to target members of STARS signalling pathway, were measured in muscle biopsies collected pre-exercise and 2 h post-exercise.

RESULTS: For the first time, we report a significant downregulation of the STARS protein in older subjects. However, there was no effect of age on the magnitude of STARS activation in response to an acute bout of exercise. Finally, we established that miR-628-5p, a miRNA regulated by age and exercise, binds to the STARS 3'UTR to directly downregulate its transcription.

CONCLUSION: This study describes for the first time the resistance exercise-induced regulation of STARS signalling in skeletal muscle from older humans and identifies a new miRNA involved in the transcriptional control of STARS.
Language eng
DOI 10.1111/apha.12819
Field of Research 110602 Exercise Physiology
1106 Human Movement And Sports Science
1116 Medical Physiology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30089687

Document type: Journal Article
Collection: Centre for Physical Activity and Nutrition Research
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