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FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials

Livingstone, Katherine M, Celis-Morales, Carlos, Papandonatos, George D, Erar, Bahar, Florez, Jose C, Jablonski, Kathleen A, Razquin, Cristina, Marti, Amelia, Heianza, Yoriko, Huang, Tao, Sacks, Frank M, Svendstrup, Mathilde, Sui, Xuemei, Church, Timothy S, Jääskeläinen, Tiina, Lindström, Jaana, Tuomilehto, Jaako, Uusitupa, Matti, Rankinen, Tuomo, Saris, Wim HM, Hansen, Torben, Pedersen, Oluf, Astrup, Arne, Sørensen, Thorkild IA, Qi, Lu, Bray, George A, Martinez-Gonzalez, Miguel A, Martinez, J Alfredo, Franks, Paul W, McCaffery, Jeanne M, Lara, Jose and Mathers, John C 2016, FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials, BMJ, vol. 354, pp. 1-11, doi: 10.1136/bmj.i4707.

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Title FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials
Author(s) Livingstone, Katherine M
Celis-Morales, Carlos
Papandonatos, George D
Erar, Bahar
Florez, Jose C
Jablonski, Kathleen A
Razquin, Cristina
Marti, Amelia
Heianza, Yoriko
Huang, Tao
Sacks, Frank M
Svendstrup, Mathilde
Sui, Xuemei
Church, Timothy S
Jääskeläinen, Tiina
Lindström, Jaana
Tuomilehto, Jaako
Uusitupa, Matti
Rankinen, Tuomo
Saris, Wim HM
Hansen, Torben
Pedersen, Oluf
Astrup, Arne
Sørensen, Thorkild IA
Qi, Lu
Bray, George A
Martinez-Gonzalez, Miguel A
Martinez, J Alfredo
Franks, Paul W
McCaffery, Jeanne M
Lara, Jose
Mathers, John C
Journal name BMJ
Volume number 354
Start page 1
End page 11
Total pages 11
Publisher BMJ Group
Place of publication London, Eng.
Publication date 2016
ISSN 1756-1833
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
BODY-MASS INDEX
DIABETES PREVENTION PROGRAM
FAT-MASS
GENETIC PREDISPOSITION
EUROPEAN ADULTS
COMMON VARIANT
OBESITY
POLYMORPHISMS
ASSOCIATION
MAINTENANCE
Summary OBJECTIVE:  To assess the effect of the FTO genotype on weight loss after dietary, physical activity, or drug based interventions in randomised controlled trials.

DESIGN:  Systematic review and random effects meta-analysis of individual participant data from randomised controlled trials.

DATA SOURCES:  Ovid Medline, Scopus, Embase, and Cochrane from inception to November 2015.

ELIGIBILITY CRITERIA FOR STUDY SELECTION:  Randomised controlled trials in overweight or obese adults reporting reduction in body mass index, body weight, or waist circumference by FTO genotype (rs9939609 or a proxy) after dietary, physical activity, or drug based interventions. Gene by treatment interaction models were fitted to individual participant data from all studies included in this review, using allele dose coding for genetic effects and a common set of covariates. Study level interactions were combined using random effect models. Metaregression and subgroup analysis were used to assess sources of study heterogeneity.

RESULTS:  We identified eight eligible randomised controlled trials for the systematic review and meta-analysis (n=9563). Overall, differential changes in body mass index, body weight, and waist circumference in response to weight loss intervention were not significantly different between FTO genotypes. Sensitivity analyses indicated that differential changes in body mass index, body weight, and waist circumference by FTO genotype did not differ by intervention type, intervention length, ethnicity, sample size, sex, and baseline body mass index and age category.

CONCLUSIONS:  We have observed that carriage of the FTO minor allele was not associated with differential change in adiposity after weight loss interventions. These findings show that individuals carrying the minor allele respond equally well to dietary, physical activity, or drug based weight loss interventions and thus genetic predisposition to obesity associated with the FTO minor allele can be at least partly counteracted through such interventions.
Language eng
DOI 10.1136/bmj.i4707
Field of Research 111104 Public Nutrition Intervention
Socio Economic Objective 920411 Nutrition
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution non-commercial licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30089693

Document type: Journal Article
Collections: School of Exercise and Nutrition Sciences
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.