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Clinical significance of initial troponin I in the grey zone in emergency department chest pain patients: a retrospective pilot study

Lee, Hwee Min, Kerr, Debra, O'H Ici, Darach and Kelly, Anne-Maree 2010, Clinical significance of initial troponin I in the grey zone in emergency department chest pain patients: a retrospective pilot study, Emergency medicine journal, vol. 27, no. 4, pp. 302-304, doi: 10.1136/emj.2009.077669.

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Title Clinical significance of initial troponin I in the grey zone in emergency department chest pain patients: a retrospective pilot study
Author(s) Lee, Hwee Min
Kerr, DebraORCID iD for Kerr, Debra orcid.org/0000-0002-2956-2432
O'H Ici, Darach
Kelly, Anne-Maree
Journal name Emergency medicine journal
Volume number 27
Issue number 4
Start page 302
End page 304
Total pages 3
Publisher BMJ Group
Place of publication London, Eng.
Publication date 2010
ISSN 1472-0205
1472-0213
Keyword(s) Acute Coronary Syndrome
Aged
Aged, 80 and over
Ambulatory Care
Biomarkers
Chest Pain
Cohort Studies
Emergency Service, Hospital
Female
Humans
Male
Middle Aged
Pilot Projects
Retrospective Studies
Treatment Outcome
Troponin I
Summary AIM: 'Normal' range for cardiac troponin I (TnI) has changed with more sensitive tests, but the validity of low-level elevations is contentious. We aimed to describe the characteristics and outcome of patients with an initial TnI level 1-5 times the upper limit of normal.

METHODS: Retrospective study of patients assessed for ACS with initial TnI level between 0.05-0.19 ng/ml. Data collected included demographics, clinical data, TnI levels and outcome. Primary outcome was the proportion of patients who had a serial TnI rise consistent with ACS.

RESULTS: 72 patients were studied; median age 71, median TIMI score 3, 66.7% male. 35 patients (48.6%) had a TnI rise consistent with ACS.

CONCLUSION: Approximately half of patients with initial TnI between 0.05-0.19 ng/ml had a TnI rise consistent with ACS. An initial TnI in this range is not, of itself, indicative of ACS. Clinical decision-making should be guided by clinical features and serial TnI measurement.
Language eng
DOI 10.1136/emj.2009.077669
Field of Research 110399 Clinical Sciences not elsewhere classified
1103 Clinical Sciences
1110 Nursing
1117 Public Health And Health Services
Socio Economic Objective 920210 Nursing
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2010, BMJ Group and the College of Emergency Medicine
Persistent URL http://hdl.handle.net/10536/DRO/DU:30089871

Document type: Journal Article
Collection: School of Nursing and Midwifery
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