Protection from traumatic brain injury in hormonally active women vs men of a similar age: a retrospective international study

Yeung, Janice H.H., Mikocka-Walus, Antonina A., Cameron, Peter A., Poon, Wai s., Ho, Hiu F., Chang, Annice, Graham, Colin A. and Rainer, Timothy H. 2011, Protection from traumatic brain injury in hormonally active women vs men of a similar age: a retrospective international study, Archives of surgery, vol. 146, no. 4, pp. 436-442, doi: 10.1001/archsurg.2011.46.

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Title Protection from traumatic brain injury in hormonally active women vs men of a similar age: a retrospective international study
Author(s) Yeung, Janice H.H.
Mikocka-Walus, Antonina A.ORCID iD for Mikocka-Walus, Antonina A. orcid.org/0000-0003-4864-3956
Cameron, Peter A.
Poon, Wai s.
Ho, Hiu F.
Chang, Annice
Graham, Colin A.
Rainer, Timothy H.
Journal name Archives of surgery
Volume number 146
Issue number 4
Start page 436
End page 442
Total pages 7
Publisher American Medical Association
Place of publication Chicago, Ill.
Publication date 2011-04
ISSN 1538-3644
Keyword(s) Adolescent
Adult
Brain Edema
Brain Injuries
Cohort Studies
Estrogens
Female
Fertility
Glasgow Outcome Scale
Hong Kong
Humans
Injury Severity Score
Male
Odds Ratio
Progesterone
Registries
Retrospective Studies
Risk Factors
Sex Factors
Victoria
Summary BACKGROUND: It has been suggested that women with traumatic brain injury have more favorable outcomes than do men because of higher levels of circulating estrogen and progesterone that may reduce brain edema.

OBJECTIVES: To determine whether there is any association between sex and mortality in TBI patients and whether there is any association between sex and brain edema. DESIGN: Retrospective cohort study using data from 2001 to 2007 collected from a trauma registry in Hong Kong and the Victorian State Trauma Registry. SETTING: Two regional trauma centers in Hong Kong and 2 adult major trauma centers and 1 pediatric trauma center in Victoria, Australia.

MAIN OUTCOME MEASURES: Mortality and brain edema.

PATIENTS: Trauma patients with an Abbreviated Injury Scale score (head) of at least 3 who were aged 12 to 45 years were included. Patients with minor head injury and undisplaced closed skull fracture were excluded.

RESULTS: Both the Hong Kong and Victorian data showed no significant difference in sex-related mortality. Increased mortality was associated with decreased systolic blood pressure and Glasgow Coma Scale score and with increased New Injury Severity Score or Injury Severity Score. In Hong Kong, brain edema was associated with female sex (P = .02), and the odds of brain edema in females were greater than for males. However, this association was not found in Victorian patients.

CONCLUSION: This study found no significant association between sex and mortality in either Victoria or Hong Kong and does not support the concept that females have better outcomes after traumatic brain injury.
Language eng
DOI 10.1001/archsurg.2011.46
Field of Research 170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
1103 Clinical Sciences
Socio Economic Objective 920499 Public Health (excl. Specific Population Health) not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2011, American Medical Association
Persistent URL http://hdl.handle.net/10536/DRO/DU:30090089

Document type: Journal Article
Collection: School of Psychology
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