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Shortened telomere length in bipolar disorder: a comparison of the early and late stages of disease

Barbé-Tuana, Florencia M., Parisi, Mariana M., Panizzutti, Bruna S., Fries, Gabriel R., Grun, Lucas K., Guma, Fatima T., Kapczinski, Flavio, Berk, Michael, Gama, Clarissa S. and Rosa, Adriane R. 2016, Shortened telomere length in bipolar disorder: a comparison of the early and late stages of disease, Revista brasileira de psiquiatria, vol. 38, no. 4, October-December, pp. 281-286, doi: 10.1590/1516-4446-2016-1910.

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Title Shortened telomere length in bipolar disorder: a comparison of the early and late stages of disease
Author(s) Barbé-Tuana, Florencia M.
Parisi, Mariana M.
Panizzutti, Bruna S.
Fries, Gabriel R.
Grun, Lucas K.
Guma, Fatima T.
Kapczinski, Flavio
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Gama, Clarissa S.
Rosa, Adriane R.
Journal name Revista brasileira de psiquiatria
Volume number 38
Issue number 4
Season October-December
Start page 281
End page 286
Total pages 6
Publisher Associação Brasileira de Psiquiatria
Place of publication Sao Paulo, Brazil
Publication date 2016-10
ISSN 1516-4446
1809-452X
Keyword(s) Bipolar disorder
telomeres
telomere shortening
senescence
genetics
oxidative stress
inflammation
mania, depression
aging
Science & Technology
Life Sciences & Biomedicine
Psychiatry
mania
depression
PITUITARY-ADRENAL AXIS
RATING-SCALE
DNA-DAMAGE
METAANALYSIS
BLOOD
ASSOCIATION
MORTALITY
Summary Objective:: Bipolar disorder (BD) has been associated with increased rates of age-related diseases, such as type II diabetes, metabolic syndrome, osteoporosis, and cardiovascular disorders. Several biological findings have been associated with age-related disorders, including increased oxidative stress, inflammation, and telomere shortening. The objective of this study was to compare telomere length among participants with BD at early and late stages and age- and gender-matched healthy controls. Methods:: Twenty-six euthymic subjects with BD and 34 healthy controls were recruited. Genomic DNA was extracted from peripheral blood and mean telomere length was measured using real-time quantitative polymerase chain reaction. Results:: Telomere length was significantly shorter in both the early and late subgroups of BD subjects when compared to the respective controls (p = 0.002 and p = 0.005, respectively). The sample size prevented additional subgroup analyses, including potential effects of medication, smoking status, and lifestyle. Conclusion:: This study is concordant with previous evidence of telomere shortening in BD, in both early and late stages of the disorder, and supports the notion of accelerated aging in BD.
Language eng
DOI 10.1590/1516-4446-2016-1910
Field of Research 110319 Psychiatry (incl Psychotherapy)
1103 Clinical Sciences
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2017, Associação Brasileira de Psiquiatria
Persistent URL http://hdl.handle.net/10536/DRO/DU:30090266

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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Created: Fri, 16 Dec 2016, 11:23:08 EST

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