Transmissible cancers in an evolutionary context

Ujvari, Beata, Papenfuss, Anthony T. and Belov, Katherine 2016, Transmissible cancers in an evolutionary context, Inside the cell, vol. 1, no. 1, pp. 17-26, doi: 10.1002/icl3.1020.

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Title Transmissible cancers in an evolutionary context
Author(s) Ujvari, BeataORCID iD for Ujvari, Beata orcid.org/0000-0003-2391-2988
Papenfuss, Anthony T.
Belov, Katherine
Journal name Inside the cell
Volume number 1
Issue number 1
Start page 17
End page 26
Total pages 10
Publisher Wiley-Blackwell
Place of publication Chichester, Eng.
Publication date 2016-01
ISSN 2375-2920
Keyword(s) cancer evolution
canine transmissible venereal tumour
clam leukaemia
micro-environment
Tasmanian devil facial tumour disease
Summary Cancer is an evolutionary and ecological process in which complex interactions between tumour cells and their environment share many similarities with organismal evolution. Tumour cells with highest adaptive potential have a selective advantage over less fit cells. Naturally occurring transmissible cancers provide an ideal model system for investigating the evolutionary arms race between cancer cells and their surrounding micro-environment and macro-environment. However, the evolutionary landscapes in which contagious cancers reside have not been subjected to comprehensive investigation. Here, we provide a multifocal analysis of transmissible tumour progression and discuss the selection forces that shape it. We demonstrate that transmissiblecancers adapt to both their micro-environment and macroenvironment,and evolutionary theories applied to organisms are also relevant to these unique diseases.
Language eng
DOI 10.1002/icl3.1020
Field of Research 111201 Cancer Cell Biology
060399 Evolutionary Biology not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C2 Other contribution to refereed journal
ERA Research output type X Not reportable
Copyright notice ©2015, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30090271

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