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Functional implications of the IL-23/IL-17 immune axis in schizophrenia

Debnath, Monojit and Berk, Michael 2016, Functional implications of the IL-23/IL-17 immune axis in schizophrenia, Molecular neurobiology, In Press, pp. 1-9, doi: 10.1007/s12035-016-0309-1.

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Title Functional implications of the IL-23/IL-17 immune axis in schizophrenia
Author(s) Debnath, Monojit
Berk, MichaelORCID iD for Berk, Michael
Journal name Molecular neurobiology
Season In Press
Start page 1
End page 9
Total pages 9
Publisher Springer
Place of publication Berlin, Germany
Publication date 2016-11-29
ISSN 1559-1182
Keyword(s) Complement
Gut microbiota
IL-23/IL-17 axis
Th17 cells
Summary The aetiology of schizophrenia seems to stem from complex interactions amongst environmental, genetic, metabolic, immunologic and oxidative components. Chronic low-grade inflammation has been persistently linked to schizophrenia, and this has primarily been based on the findings derived from Th1/Th2 cytokine balance. While the IL-23/IL-17 axis plays crucial role in the pathogenesis of several immune-mediated disorders, it has remained relatively unexplored in neuropsychiatric disorders. Altered levels of cytokines related to IL-23/IL-17 axis have been observed in schizophrenia patients in a few studies. In addition, other indirect factors known to confer schizophrenia risk like complement activation and altered gut microbiota are shown to modulate the IL-23/IL-17 axis. These preliminary observations provide crucial clues about the functional implications of IL-23/IL-17 axis in schizophrenia. In this review, an attempt has been made to highlight the biology of IL-23/IL-17 axis and its relevance to schizophrenia risk and pathogenesis. Given the pathogenic potential of the IL-23/IL-17 axis, therapeutic targeting of this axis may be a promising approach to benefit patients suffering from this devastating disorder.
Language eng
DOI 10.1007/s12035-016-0309-1
Field of Research 110319 Psychiatry (incl Psychotherapy)
1109 Neurosciences
1702 Cognitive Science
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Springer
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Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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Created: Fri, 16 Dec 2016, 16:15:23 EST

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