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Mycobacterium ulcerans in the elderly: more severe disease and suboptimal outcomes

O’Brien, Daniel P., Friedman, N. Deborah, Cowan, Raquel, Pollard, James, McDonald, Anthony, Callan, Peter, Hughes, Andrew and Athan, Eugene 2015, Mycobacterium ulcerans in the elderly: more severe disease and suboptimal outcomes, PLoS neglected tropical diseases, vol. 9, no. 12, pp. 1-10, doi: 10.1371/journal.pntd.0004253.

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Title Mycobacterium ulcerans in the elderly: more severe disease and suboptimal outcomes
Author(s) O’Brien, Daniel P.
Friedman, N. Deborah
Cowan, Raquel
Pollard, JamesORCID iD for Pollard, James orcid.org/0000-0001-9984-2870
McDonald, Anthony
Callan, Peter
Hughes, Andrew
Athan, EugeneORCID iD for Athan, Eugene orcid.org/0000-0001-9838-6471
Journal name PLoS neglected tropical diseases
Volume number 9
Issue number 12
Article ID e0004253
Start page 1
End page 10
Total pages 10
Publisher PLoS
Place of publication San Francisco, Calif.
Publication date 2015-12-02
ISSN 1935-2735
Summary Mycobacterium ulcerans is an infection that can affect all age-groups. It causes necrosis of skin and soft-tissue often resulting in severe outcomes and long-term disability. However, due to the majority of infections worldwide occurring in children and young adults, there is a paucity of information available in elderly patients. It is important that elderly patients are not neglected as the clinical presentation and treatment outcomes may differ significantly from younger patients related to relative immune defficiencies, co-morbidities and increased potential for drug interactions. We specifically examined patients with M. ulcerans disease aged ≥ 65 years and showed that they comprise a significant proportion of patients affected in Australian populations. They present with more severe and advanced disease forms, and suffer from increased toxicity and reduced effectiveness of the currently recommended treatments. Therefore, our study demonstrates that increased efforts are required to diagnose M. ulcerans disease earlier in elderly populations, and that research is urgently required to develop more effective and less toxic treatments for this age-group.
Language eng
DOI 10.1371/journal.pntd.0004253
Field of Research 110399 Clinical Sciences not elsewhere classified
06 Biological Sciences
11 Medical And Health Sciences
Socio Economic Objective 0 Not Applicable
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30090392

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.