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Enhancement of neural cell lines proliferation using nano-structured chitosan/poly(vinyl alcohol) scaffolds conjugated with nerve growth factor

Mottaghitalab, Fatemeh, Farokhi, Mehdi, Mottaghitalab, Vahid, Ziabari, Mohammad, Divsalar, Adeleh and Shokrgozar, Mohammad Ali 2011, Enhancement of neural cell lines proliferation using nano-structured chitosan/poly(vinyl alcohol) scaffolds conjugated with nerve growth factor, Carbohydrate polymers, vol. 86, no. 2, pp. 526-535, doi: 10.1016/j.carbpol.2011.04.066.

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Title Enhancement of neural cell lines proliferation using nano-structured chitosan/poly(vinyl alcohol) scaffolds conjugated with nerve growth factor
Author(s) Mottaghitalab, Fatemeh
Farokhi, Mehdi
Mottaghitalab, Vahid
Ziabari, MohammadORCID iD for Ziabari, Mohammad orcid.org/0000-0001-7322-0387
Divsalar, Adeleh
Shokrgozar, Mohammad Ali
Journal name Carbohydrate polymers
Volume number 86
Issue number 2
Start page 526
End page 535
Total pages 10
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2011-08-15
ISSN 0144-8617
Keyword(s) neural tissue engineering
chitosan
poly(vinyl alcohol)
nerve growth factor
electrospinning
Summary Chitosan/poly(vinyl alcohol) (CS/PVA) conjugated nerve growth factor (NGF) scaffolds for potential neural tissue engineering purposes were prepared using electrospinning. NGF was incorporated onto the electrospun nanofibers to mimic the biochemical properties of the neural tissue. Upon current protocol, cell proliferation significantly imitates by ECM surface topography, matrix porosity, surface area, and chemical structure of electrospun scaffolds. CS/PVA conjugated NGF scaffolds were further assessed in terms of attachment and proliferation of SKNMC and U373 cell lines. The thermodynamic parameters of binding of NGF on CS/PVA scaffolds and the NGF releasing rate were evaluated. It has been shown that the electrospun CS/PVA conjugated NGF nanocomposite fibers possess high surface-area-to-volume ratio to support the attachment and proliferation rate of both cell types.
Language eng
DOI 10.1016/j.carbpol.2011.04.066
Field of Research 060103 Cell Development, Proliferation and Death
0305 Organic Chemistry
0908 Food Sciences
0303 Macromolecular And Materials Chemistry
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2011, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30090421

Document type: Journal Article
Collection: Institute for Frontier Materials
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