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Long-term prognostic significance of periprocedural myonecrosis in patients with stable coronary artery disease undergoing elective percutaneous coronary intervention

Mok, Michael, Yudi, Matias B., Goh, Cheng Yee, Clark, David J., Ramchand, Jay, Al-Fiadh, Ali, Jones, Nicholas, Fernando, Dharsh, Lu, Ken and Farouque, Omar 2016, Long-term prognostic significance of periprocedural myonecrosis in patients with stable coronary artery disease undergoing elective percutaneous coronary intervention, Asia intervention, vol. 2, pp. 121-128, doi: 10.4244/AsiaInterv_V2I2A25.

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Title Long-term prognostic significance of periprocedural myonecrosis in patients with stable coronary artery disease undergoing elective percutaneous coronary intervention
Author(s) Mok, Michael
Yudi, Matias B.
Goh, Cheng Yee
Clark, David J.
Ramchand, Jay
Al-Fiadh, Ali
Jones, Nicholas
Fernando, Dharsh
Lu, Ken
Farouque, Omar
Journal name Asia intervention
Volume number 2
Start page 121
End page 128
Total pages 8
Publisher Europa Digital & Publishing
Place of publication Toulouse, France
Publication date 2016-08
Summary The clinical significance of myonecrosis, measured by cardiac troponin, in the context of percutaneous coronary intervention (PCI) is a matter of ongoing debate. The lack of substantial scientific evidence in this domain is apparent from the ever-changing definitions of periprocedural myocardial infarction and the uncertainty regarding its prognostic relevance.Myonecrosis due to PCI is common and occurs in up to 40% of cases, depending on the definition and biomarker used5. In the Third Universal Definition of Myocardial Infarction (MI), the cutoff cardiac troponin level to diagnose myonecrosis increased from 3 to 5 times the upper reference limit (URL). In contrast to previous definitions, troponin elevation needs to be associated with clinical, electrocardiographic, angiographic or cardiac imagingrelated evidence of ischaemia to be classified as a periprocedural MI, or type 4a MI. However, the occurrence of post-PCI chest pain without troponin elevation and troponin elevation without chest pain, angiographic complications or other signs of ischaemia is well documented. The Society of Cardiovascular Angiography and Interventions (SCAI) has proposed an alternative definition of “clinically significant myocardial infarction” requiring troponin levels of ≥70x upper limit of normal (ULN) or ≥35x ULN with electrocardiographic evidence of infarction.
Language eng
DOI 10.4244/AsiaInterv_V2I2A25
Field of Research 110201 Cardiology (incl Cardiovascular Diseases)
Socio Economic Objective 920103 Cardiovascular System and Diseases
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Europa Digital & Publishing
Persistent URL http://hdl.handle.net/10536/DRO/DU:30090463

Document type: Journal Article
Collections: School of Medicine
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