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Muscle damage and inflammation during recovery from exercise

Peake, Jonathan M., Neubauer, Oliver, Della Gatta, Paul A. and Nosaka, Kazunori 2017, Muscle damage and inflammation during recovery from exercise, Journal of applied physiology, vol. 122, no. 3, pp. 559-570, doi: 10.1152/japplphysiol.00971.2016.

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Title Muscle damage and inflammation during recovery from exercise
Author(s) Peake, Jonathan M.
Neubauer, Oliver
Della Gatta, Paul A.ORCID iD for Della Gatta, Paul A.
Nosaka, Kazunori
Journal name Journal of applied physiology
Volume number 122
Issue number 3
Start page 559
End page 570
Total pages 12
Publisher American Physiological Society
Place of publication Bethesda, Md.
Publication date 2017-03-01
ISSN 1522-1601
Keyword(s) cytokines
eccentric exercise
Summary Unaccustomed exercise consisting of eccentric (i.e., lengthening) muscle contractions often results in muscle damage characterized by ultrastructural alterations in muscle tissue, clinical signs and symptoms (e.g., reduced muscle strength and range of motion, increased muscle soreness and swelling, efflux of myocellular proteins). The time course of recovery following exercise-induced muscle damage depends on the extent of initial muscle damage, which in turn is influenced by the intensity and duration of exercise, joint angle/muscle length and muscle groups used during exercise. The effects of these factors on muscle strength, soreness and swelling are well characterized. By contrast, much less is known about how they affect intramuscular inflammation and molecular aspects of muscle adaptation/remodeling. Although inflammation has historically been viewed as detrimental for recovery from exercise, it is now generally accepted that inflammatory responses-if tightly regulated-are integral to muscle repair and regeneration. Animal studies have revealed that other cell types including mast cells, eosinophils, CD8 and T regulatory lymphocytes, fibro-adipogenic progenitors and pericytes also help to facilitate muscle tissue regeneration. However, more research is required to determine whether these cells respond to exercise-induced muscle damage. A large body of research has investigated the efficacy of physicotherapeutic, pharmacological and nutritional interventions for reducing the signs and symptoms of exercise-induced muscle damage, with mixed results. More research is needed to examine if/how these treatments influence inflammation and muscle remodeling during recovery from exercise.
Language eng
DOI 10.1152/japplphysiol.00971.2016
Field of Research 110604 Sports Medicine
06 Biological Sciences
11 Medical And Health Sciences
Socio Economic Objective 920409 Injury Control
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2017, American Physiological Society
Free to Read? No
Free to Read Start Date 2018-03-01
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Document type: Journal Article
Collection: School of Life and Environmental Sciences
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Created: Wed, 11 Jan 2017, 11:08:56 EST

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