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MicroRNA expression patterns in post-natal mouse skeletal muscle development

Lamon, Severine, Zacharewicz, Evelyn, Butchart, Lauren C., Orellana, Liliana, Mikovic, Jasmine, Grounds, Miranda D. and Russell, Aaron P. 2017, MicroRNA expression patterns in post-natal mouse skeletal muscle development, BMC genomics, vol. 18, Article Number : 52, pp. 1-13, doi: 10.1186/s12864-016-3399-2.

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Title MicroRNA expression patterns in post-natal mouse skeletal muscle development
Author(s) Lamon, SeverineORCID iD for Lamon, Severine orcid.org/0000-0002-3271-6551
Zacharewicz, Evelyn
Butchart, Lauren C.
Orellana, LilianaORCID iD for Orellana, Liliana orcid.org/0000-0003-3736-4337
Mikovic, Jasmine
Grounds, Miranda D.
Russell, Aaron P.ORCID iD for Russell, Aaron P. orcid.org/0000-0002-7323-9501
Journal name BMC genomics
Volume number 18
Season Article Number : 52
Start page 1
End page 13
Total pages 13
Publisher BioMed Central
Place of publication London, Eng.
Publication date 2017
ISSN 1471-2164
Keyword(s) Cell differentiation
Cell proliferation
Growth
MiRNAs
Myogenesis
Skeletal muscle
Summary BACKGROUND: MiRNAs are essential regulators of skeletal muscle development and homeostasis. To date, the role and regulation of miRNAs in myogenesis have been mostly studied in tissue culture and during embryogenesis. However, little information relating to miRNA regulation during early post-natal skeletal muscle growth in mammals is available. Using a high-throughput miRNA qPCR-based array, followed by stringent statistical and bioinformatics analysis, we describe the expression pattern and putative role of 768 miRNAs in the quadriceps muscle of mice aged 2 days, 2 weeks, 4 weeks and 12 weeks.

RESULTS: Forty-six percent of all measured miRNAs were expressed in mouse quadriceps muscle during the first 12 weeks of life. We report unprecedented changes in miRNA expression levels over time. The expression of a majority of miRNAs significantly decreased with post-natal muscle maturation in vivo. MiRNA clustering identified 2 subsets of miRNAs that are potentially involved in cell proliferation and differentiation, mainly via the regulation of non-muscle specific targets.

CONCLUSION: Collective miRNA expression in mouse quadriceps muscle is subjected to substantial levels of regulation during the first 12 weeks of age. This study identified a new suite of highly conserved miRNAs that are predicted to influence early muscle development. As such it provides novel knowledge pertaining to post-natal myogenesis and muscle regeneration in mammals.
Language eng
DOI 10.1186/s12864-016-3399-2
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2017, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30090537

Document type: Journal Article
Collections: Faculty of Health
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.