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Characteristics of patients with haematological and breast cancer (1996-2009) who died of heart failure-related causes after cancer therapy

Versace, Vincent L., Berry, Narelle M., Chowdhury, Munir H., Ullah, Shahid, McCarthy, Alexandra L., Atherton, John J., Koczwara, Bogda, Roder, David and Clark, Robyn A. 2016, Characteristics of patients with haematological and breast cancer (1996-2009) who died of heart failure-related causes after cancer therapy, ESC heart failure, vol. 3, no. 4, pp. 253-260, doi: 10.1002/ehf2.12099.

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Title Characteristics of patients with haematological and breast cancer (1996-2009) who died of heart failure-related causes after cancer therapy
Author(s) Versace, Vincent L.ORCID iD for Versace, Vincent L. orcid.org/0000-0002-8514-1763
Berry, Narelle M.
Chowdhury, Munir H.
Ullah, Shahid
McCarthy, Alexandra L.
Atherton, John J.
Koczwara, Bogda
Roder, David
Clark, Robyn A.
Journal name ESC heart failure
Volume number 3
Issue number 4
Start page 253
End page 260
Total pages 8
Publisher John Wiley & Sons
Place of publication Chichester, Eng.
Publication date 2016-12
ISSN 2055-5822
Keyword(s) cardiotoxicity
mortality
haematological
breast
cancer
heart failure
Summary Aims To describe the characteristics and time to death of patients with breast or haematological cancer who died of heart failure (HF) after cancer therapy. Patients with an index admission for HF who died of HF-related causes (IAHF) and those with no index admission for HF who died of HF-related causes (NIAHF) were compared.

Methods and results We performed a linked data analysis of cancer registry, death registry, and hospital administration records (n = 15 987). Index HF admission must have occurred after cancer diagnosis. Of the 4894 patients who were deceased (30.6% of cohort), 734 died of HF-related causes (50.1% female) of which 279 (38.0%) had at least one IAHF (41.9% female) post-cancer diagnosis. Median age was 71 years [interquartile range (IQR) 62–78] for IAHF and 66 years (IQR 56–74) for NIAHF. There were fewer chemotherapy separations for IAHF patients (median = 4, IQR 2–9) compared with NIAHF patients (median = 6, IQR 2–12). Of the IAHF patients, 71% had died within 1 year of the index HF admission. There was no significant difference in HF-related mortality in IAHF patients compared with NIAHF (HR, 1.10, 95% CI, 0.94–1.29, P = 0.225).

Conclusions
The profile of IAHF patients who died of HF-related causes after cancer treatment matched the current profile of HF in the general population (over half were aged ≥70 years). However, NIAHF were younger (62% were aged ≤69 years), female patients with breast cancer that died of HF-related causes before hospital admission for HF-related causes—a group that may have been undiagnosed or undertreated until death.
Language eng
DOI 10.1002/ehf2.12099
Field of Research 111799 Public Health and Health Services not elsewhere classified
Socio Economic Objective 920499 Public Health (excl. Specific Population Health) not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution Non-Commercial No-Derivatives licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30090560

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.