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Cancer: a disease at the crossroads of trade-offs

Jacqueline, Camille, Biro, Peter A., Beckmann, Christa, Moller, Anders Pape, Renaud, François, Sorci, Gabriele, Tasiemski,  Aurélie, Ujvari, Beata and Thomas, Frédéric 2017, Cancer: a disease at the crossroads of trade-offs, Evolutionary applications: evolutionary approaches to environmental, biomedical and socio-economic issues, vol. 10, no. 3, pp. 215-225, doi: 10.1111/eva.12444.

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Title Cancer: a disease at the crossroads of trade-offs
Author(s) Jacqueline, Camille
Biro, Peter A.ORCID iD for Biro, Peter A. orcid.org/0000-0002-3565-240X
Beckmann, ChristaORCID iD for Beckmann, Christa orcid.org/0000-0002-7904-7228
Moller, Anders Pape
Renaud, François
Sorci, Gabriele
Tasiemski,  Aurélie
Ujvari, BeataORCID iD for Ujvari, Beata orcid.org/0000-0003-2391-2988
Thomas, Frédéric
Journal name Evolutionary applications: evolutionary approaches to environmental, biomedical and socio-economic issues
Volume number 10
Issue number 3
Start page 215
End page 225
Total pages 11
Publisher Wiley
Place of publication London, Eng.
Publication date 2017-03
ISSN 1752-4563
1752-4571
Keyword(s) cancer
life-history traits
natural selectio
trade-off
life‐history traits
natural selection
trade‐off
Science & Technology
Life Sciences & Biomedicine
Evolutionary Biology
life-history traits
FACIAL-TUMOR DISEASE
PROSTATE-CANCER
EVOLUTIONARY DYNAMICS
IMMUNE-RESPONSE
BREAST-CANCER
MATE CHOICE
DNA-DAMAGE
STEM-CELLS
RISK
Summary Central to evolutionary theory is the idea that living organisms face phenotypic and/or genetic trade-offs when allocating resources to competing life-history demands, such as growth, survival, and reproduction. These trade-offs are increasingly considered to be crucial to further our understanding of cancer. First, evidences suggest that neoplastic cells, as any living entities subject to natural selection, are governed by trade-offs such as between survival and proliferation. Second, selection might also have shaped trade-offs at the organismal level, especially regarding protective mechanisms against cancer. Cancer can also emerge as a consequence of additional trade-offs in organisms (e.g., eco-immunological trade-offs). Here, we review the wide range of trade-offs that occur at different scales and their relevance for understanding cancer dynamics. We also discuss how acknowledging these phenomena, in light of human evolutionary history, may suggest new guidelines for preventive and therapeutic strategies.
Language eng
DOI 10.1111/eva.12444
Field of Research 111201 Cancer Cell Biology
060303 Biological Adaptation
0603 Evolutionary Biology
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30090642

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.