The extracellular matrix in cancer progression: role of hyalectan proteoglycans and ADAMTS enzymes

Binder, Marley J, McCoombe, Scott, Williams, Elizabeth D, McCulloch, Daniel R and Ward, Alister C 2017, The extracellular matrix in cancer progression: role of hyalectan proteoglycans and ADAMTS enzymes, Cancer letters, vol. 385, pp. 55-64, doi: 10.1016/j.canlet.2016.11.001.

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Title The extracellular matrix in cancer progression: role of hyalectan proteoglycans and ADAMTS enzymes
Author(s) Binder, Marley J
McCoombe, ScottORCID iD for McCoombe, Scott
Williams, Elizabeth D
McCulloch, Daniel R
Ward, Alister CORCID iD for Ward, Alister C
Journal name Cancer letters
Volume number 385
Start page 55
End page 64
Total pages 10
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2017-01-28
ISSN 0304-3835
Keyword(s) ADAMTS
Extracellular matrix
Science & Technology
Life Sciences & Biomedicine
Chrondroitin sulfate proteoglycan
Hyaluronan-binding proteins
Stage prostate-cancer
Epithelial ovarian-cancer
Rich pericullular matrix
Cell-surface hyaluronan
Human breast-carcinoma
Mouse PG-M
Versican expression
Androgen receptor
Summary Remodelling of the extracellular matrix (ECM) has emerged as a key factor in cancer progression. Proteoglycans, including versican and other hyalectans, represent major structural elements of the ECM where they interact with other important molecules, including the glycosaminoglycan hyaluronan and the CD44 cell surface receptor. The hyalectan proteoglycans are regulated through cleavage by the proteolytic actions of A Disintegrin-like And Metalloproteinase domain with Thrombospondin-1 motif (ADAMTS) family members. Alteration in the balance between hyalectan proteoglycans and ADAMTS enzymes has been proposed to be a crucial factor in cancer progression either in a positive or negative manner depending on the context. Further complexity arises due to the formation of bioactive cleavage products, such as versikine, which may also play a role, and non-enzymatic functions for ADAMTS proteins. This research is providing fresh insights into cancer biology and opportunities for the development of new diagnostic and treatment strategies.
Language eng
DOI 10.1016/j.canlet.2016.11.001
Field of Research 111299 Oncology and Carcinogenesis not elsewhere classified
1112 Oncology And Carcinogenesis
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Elsevier Ireland Ltd
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Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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