You are not logged in.

Cannabinoid receptors on peripheral leukocytes from patients with schizophrenia: evidence for defective immunomodulatory mechanisms

de Campos-Carli, Salvina Maria, Araújo, Marcio Sobreira, de Oliveira Silveira, Amanda Cardoso, de Rezende, Vitor Bortolo, Rocha, Natalia Pessoa, Ferretjans, Rodrigo, Ribeiro-Santos, Rafael, Teixeira-Carvalho, Andrea, Martins-Filho, Olinda Assis, Berk, Michael, Salgado, Joao Vinicius and Teixeira, Antonio Lucio 2017, Cannabinoid receptors on peripheral leukocytes from patients with schizophrenia: evidence for defective immunomodulatory mechanisms, Journal of psychiatric research, vol. 87, pp. 44-52, doi: 10.1016/j.jpsychires.2016.12.001.

Attached Files
Name Description MIMEType Size Downloads

Title Cannabinoid receptors on peripheral leukocytes from patients with schizophrenia: evidence for defective immunomodulatory mechanisms
Author(s) de Campos-Carli, Salvina Maria
Araújo, Marcio Sobreira
de Oliveira Silveira, Amanda Cardoso
de Rezende, Vitor Bortolo
Rocha, Natalia Pessoa
Ferretjans, Rodrigo
Ribeiro-Santos, Rafael
Teixeira-Carvalho, Andrea
Martins-Filho, Olinda Assis
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Salgado, Joao Vinicius
Teixeira, Antonio Lucio
Journal name Journal of psychiatric research
Volume number 87
Start page 44
End page 52
Total pages 9
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2017-04
ISSN 1879-1379
Keyword(s) Cannabinoid receptors
Cytokines
Endocannabinoid system
Inflammation
Leukocytes
Schizophrenia
Summary OBJECTIVES: to evaluate cannabinoid receptors (CBRs) expression on peripheral immune cells, i.e., blood monocytes, neutrophils, lymphocytes, and NK cells, and their relationship to a wide range of serum cytokine levels in subjects with schizophrenia and controls.

METHODS: A sample of 55 people with chronic schizophrenia and 48 controls were enrolled in the study. The expression of the cannabinoid receptors CB1R and CB2R was evaluated in peripheral blood leukocytes by flow cytometry. Serum levels of cytokines/chemokines were simultaneously analyzed by cytometric bead array.

RESULTS: We found higher expression of cannabinoid receptors on cells of the innate immune system in subjects with schizophrenia when compared with controls. Serum levels of interleukin-4 (IL-4), IL-6, IL-10, IL-17, interferon (IFN-γ), and (C-X-C motif) ligand 10/interferon gamma-induced protein 10 (CXCL10/IP10) were decreased, while levels of the chemokine (C-C motif) ligand 2/monocyte chemoattractant protein-1 (CCL2/MCP-1) were increased in the schizophrenia group in comparison with controls. Patients with schizophrenia showed simpler correlation network between cytokines and CBRs expression than controls.

CONCLUSION: Patients with schizophrenia showed increased CBRs expression in cells of the innate immune system and simpler correlation network between cytokines and CBRs expression when compared with controls. These results suggest a defective endocannabinoid system-mediated immunomodulation in patients with schizophrenia.
Language eng
DOI 10.1016/j.jpsychires.2016.12.001
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30090727

Document type: Journal Article
Collection: School of Medicine
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in TR Web of Science
Scopus Citation Count Cited 0 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 31 Abstract Views, 1 File Downloads  -  Detailed Statistics
Created: Thu, 19 Jan 2017, 14:40:30 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.