Are patients on warfarin with high INR treated according to published guidelines?

Le-Kim, Lucia, Kerr, Debra and Kelly, Anne-Maree 2009, Are patients on warfarin with high INR treated according to published guidelines?, Internet journal of hematology, vol. 5, no. 1, pp. 1-8.

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Title Are patients on warfarin with high INR treated according to published guidelines?
Author(s) Le-Kim, Lucia
Kerr, DebraORCID iD for Kerr, Debra
Kelly, Anne-Maree
Journal name Internet journal of hematology
Volume number 5
Issue number 1
Start page 1
End page 8
Total pages 8
Publisher Internet Scientific Publications
Place of publication Sugar Land, Tex.
Publication date 2009
ISSN 1540-2649
Summary Objective: Australasian guidelines for the treatment of over-anticoagulation have been published. We aimed to determine whether emergency department [ED] patients taking warfarin who have high INR were treated according to guidelines.

Methods: This retrospective observational study included ED patients taking warfarin with INR ≥ 4. Data included demographics, warfarin indication, bleeding evidence and subsequent management. Outcome of interest was proportion treated according to guidelines; analysed by descriptive statistics.

Results: 201 patients were studied; median age 74 years, 47% female. Atrial fibrillation was the main indication for warfarin [63%]. 48 patients [24%] presented with bleeding, of which 22 were classified as major bleeds. All patients with major bleeding received reversal treatment; with 64% receiving recommended triple therapy. 33% in the non-bleeding group received reversal treatment.

Conclusion: There was reasonably good compliance with the guidelines, especially for patients with major bleeding. Vitamin K doses were suboptimal in a significant proportion of cases.
Language eng
Field of Research 111799 Public Health and Health Services not elsewhere classified
1102 Cardiovascular Medicine And Haematology
Socio Economic Objective 920499 Public Health (excl. Specific Population Health) not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©[2009, Internet Scientific Publications]
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