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Subclinic effect of administration of T-2 toxin and nivalenol in mice

Pacin, Ana, Reale, Carlos, Mirengui, Hebe, Orellana, Graciela and Boente, Graciela 1994, Subclinic effect of administration of T-2 toxin and nivalenol in mice, Mycotoxin research, vol. 10, pp. 85-96.

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Title Subclinic effect of administration of T-2 toxin and nivalenol in mice
Author(s) Pacin, Ana
Reale, Carlos
Mirengui, Hebe
Orellana, GracielaORCID iD for Orellana, Graciela orcid.org/0000-0003-3736-4337
Boente, Graciela
Journal name Mycotoxin research
Volume number 10
Start page 85
End page 96
Total pages 12
Publisher Hans W. Schmidt
Place of publication Mainz, Germany
Publication date 1994
ISSN 0178-7888
1867-1632
Summary Four experiments using T-2 toxin and nivalenol at different dosage, which represented the 25% and 40% of the LD50 (experiment A: 1.04 mg of T-2 toxin per kilogram of body weight, experiment B:2.34 mg of T-2 toxin/kg b.w.; experiment D: 0.82 mg of nivalenol/kg b.w. and 1.845 mg nivalenol/kg b.w.) were conducted on 400 mice. Both toxins were administered to mice of different ages (experiments A and B were adults, experiment C and D were young) by intraperitoneal single injection, and the clinical signs, hematological variables and histoanatomo pathological changes were studied. All animals survived. No changes anatomo-histopathological nor significative differences in weight gain were observed. Different behaviors were found for nivalenol and T-2 toxin. The most significant change as the increase in the level of monocytes in old animals, so this could be a biological indicator for T-2 tocin subclinical intoxication.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©[1994, Hans W. Schmidt]
Persistent URL http://hdl.handle.net/10536/DRO/DU:30090772

Document type: Journal Article
Collection: Faculty of Health
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