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Antidepressants in inflammatory bowel disease: a systematic review

Macer, Benjamin J. D., Prady, Stephanie L. and Mikocka-Walus, Antonina 2017, Antidepressants in inflammatory bowel disease: a systematic review, Inflammatory bowel diseases, vol. 23, no. 4, pp. 534-550, doi: 10.1097/MIB.0000000000001059.

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Title Antidepressants in inflammatory bowel disease: a systematic review
Author(s) Macer, Benjamin J. D.
Prady, Stephanie L.
Mikocka-Walus, AntoninaORCID iD for Mikocka-Walus, Antonina orcid.org/0000-0003-4864-3956
Journal name Inflammatory bowel diseases
Volume number 23
Issue number 4
Start page 534
End page 550
Total pages 17
Publisher Lippincott Williams & Wilkins
Place of publication Philadelphia, Pa.
Publication date 2017-03-06
ISSN 1078-0998
Keyword(s) antidepressants
anxiety
depression
inflammatory bowel disease
systematic review
Summary Background: Antidepressants are commonly used to treat symptoms of anxiety and depression in inflammatory bowel disease (IBD). Recent studies suggest a link between IBD activity and an individual’s emotional state which raises the possibility that antidepressants may potentially modify the disease course of IBD. This systematic review thus primarily aims to evaluate the efficacy of antidepressants on IBD activity, and secondarily, on anxiety and depression. Methods: MEDLINE, EMBASE, Cochrane (IBD Group), CINAHL, AMED, PsycINFO and Open Grey were searched from 1990 onwards with no restrictions on study design. A quality appraisal was conducted using several scales as appropriate for each study design. A narrative synthesis was also conducted.Results: Fifteen eligible studies included in the review (1 RCT, 2 cohorts, 1 case-control, 1 cross-sectional survey, 1 qualitative, 2 audits, 1 case-series and 6 case reports) examined a range of antidepressants. Twelve studies suggested antidepressants have a positive impact on IBD course. Nine studies reported anxiety and depression as an outcome, of these eight reported beneficial effects of antidepressants. Most of the studies were deemed to be at low risk of bias, apart from the case reports, which were at high risk of bias.Conclusions: The current research indicates antidepressants may have a beneficial effect on IBD course. However, it is currently not possible to determine their efficacy for certain due the lack of randomised trials. Further trials using objective measures of IBD activity, longer follow-up periods and larger sample sizes are needed.
Language eng
DOI 10.1097/MIB.0000000000001059
Field of Research 110307 Gastroenterology and Hepatology
170106 Health, Clinical and Counselling Psychology
1103 Clinical Sciences
Socio Economic Objective 920105 Digestive System Disorders
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2017, Crohn's & Colitis Foundation of America
Free to Read? No
Free to Read Start Date 2018-03-07
Persistent URL http://hdl.handle.net/10536/DRO/DU:30090795

Document type: Journal Article
Collection: School of Psychology
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