Controversies surrounding the comorbidity of depression and anxiety in inflammatory bowel disease patients: a literature review

Mikocka-Walus, Antonina A., Turnbull, Debora A., Moulding, Nicole T., Wilson, Ian G., Andrews, Jane M. and Holtmann, Gerald J. 2007, Controversies surrounding the comorbidity of depression and anxiety in inflammatory bowel disease patients: a literature review, Inflammatory bowel diseases, vol. 13, no. 2, pp. 225-234, doi: 10.1002/ibd.20062.

Attached Files
Name Description MIMEType Size Downloads

Title Controversies surrounding the comorbidity of depression and anxiety in inflammatory bowel disease patients: a literature review
Author(s) Mikocka-Walus, Antonina A.ORCID iD for Mikocka-Walus, Antonina A.
Turnbull, Debora A.
Moulding, Nicole T.
Wilson, Ian G.
Andrews, Jane M.
Holtmann, Gerald J.
Journal name Inflammatory bowel diseases
Volume number 13
Issue number 2
Start page 225
End page 234
Total pages 10
Publisher Lippincott Williams & Wilkins
Place of publication Philadelphia, Pa.
Publication date 2007
ISSN 1078-0998
Keyword(s) inflammatory bowel disease
Summary Psychological disorders are highly prevalent in patients with inflammatory bowel disease (IBD). Anxiety and depression are known to independently affect quality of life and may additionally impair quality of life in IBD over and above the IBD itself. Some researchers have further proposed that anxiety and depression may influence the clinical course of IBD. However, despite the potential for anxiety and depression to play an important role in the clinical picture of IBD, there is little prospective well-controlled research in this area. Probably because of this lack of clear data, researchers dispute the actual role of these psychological disorders in IBD, with a number of conflicting opinions expressed. This article reports on a review of the literature in this field. Herein we discuss the five main areas of controversy regarding IBD and the specific psychological comorbidities of depression and anxiety: 1) the relative rate of cooccurrence of these psychological disorders with IBD; 2) the cooccurrence of these psychological disorders with particular phase of IBD; 3) the cooccurrence of these psychological disorders with the specific type of IBD; 4) the rate of these psychological comorbidities compared both to healthy subjects and to other disease states; and 5) the timing of onset of psychological comorbidity with respect to onset of IBD. Methodological weaknesses of the reviewed studies make it impossible to resolve these controversies. However, the results clearly show that anxiety/depression and IBD frequently interact. Given the long-term illness burden patients with IBD face, further prospective, appropriately controlled studies are needed to adequately answer the question of the precise interplay between anxiety/depression and IBD.
Language eng
DOI 10.1002/ibd.20062
Field of Research 110307 Gastroenterology and Hepatology
110319 Psychiatry (incl Psychotherapy)
1103 Clinical Sciences
Socio Economic Objective 920105 Digestive System Disorders
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2006, Crohn's & Colitis Foundation of America
Persistent URL

Document type: Journal Article
Collections: Faculty of Health
School of Psychology
Connect to link resolver
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 96 times in TR Web of Science
Scopus Citation Count Cited 106 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 173 Abstract Views, 1 File Downloads  -  Detailed Statistics
Created: Mon, 06 Feb 2017, 08:11:06 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact