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A systematic review and meta-analysis of prospective transition from major depression to bipolar disorder

Ratheesh, A, Davey, C, Hetrick, S, Alvarez-Jimenez, M, Voutier, C, Bechdolf, A, McGorry, PD, Scott, J, Berk, Michael and Cotton, SM 2017, A systematic review and meta-analysis of prospective transition from major depression to bipolar disorder, Acta psychiatrica Scandinavica, vol. 135, no. 4, pp. 273-284, doi: 10.1111/acps.12686.

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Title A systematic review and meta-analysis of prospective transition from major depression to bipolar disorder
Author(s) Ratheesh, A
Davey, C
Hetrick, S
Alvarez-Jimenez, M
Voutier, C
Bechdolf, A
McGorry, PD
Scott, J
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Cotton, SM
Journal name Acta psychiatrica Scandinavica
Volume number 135
Issue number 4
Start page 273
End page 284
Total pages 12
Publisher Wiley-Blackwell
Place of publication London, Eng.
Publication date 2017-04
ISSN 0001-690X
1600-0447
Keyword(s) affective disorders
bipolar disorder
depression
meta-analysis
risk factors
science & technology
life sciences & biomedicine
psychiatry
prospective follow-up
psychotic features
diagnostic conversion
unipolar depression
prodromal features
mood disorders
risk-factors
predictors
illness
mania
Summary Some people with major depressive disorder (MDD) may be at a pre-onset stage for bipolar disorder (BD), where early identification or prevention efforts may be feasible. We aimed to identify rates and characteristics predictive of transition to BD in prospective follow-up studies of people with MDD. Using a systematic search strategy, we identified studies with a diagnostic ascertainment of MDD and BD of an adequate standard, and where the minimum length of follow-up was 6 months. We examined the incidence and point prevalence of BD and the pooled odds ratios (OR) for baseline predictors. From 5554 unique publications, 56 were included. Nearly a quarter of adults (22.5%) and adolescents with MDD followed up for a mean length of 12-18 years developed BD, with the greatest risk of transition being in the first 5 years. The meta-analysis identified that transition from MDD to BD was predicted by family history of BD (OR = 2.89, 95% CI: 2.01-4.14, N = 7), earlier age of onset of depression (g = -0.33, SE = 0.05, N = 6) and presence of psychotic symptoms (OR = 4.76, 95% CI: 1.79-12.66, N = 5). Participants with the identified risk factors merit closer observation and may benefit from prevention efforts, especially if outcomes broader than BD are considered.
Language eng
DOI 10.1111/acps.12686
Field of Research 110319 Psychiatry (incl Psychotherapy)
11 Medical And Health Sciences
17 Psychology And Cognitive Sciences
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2017, John Wiley & Sons A/S.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30091208

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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