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Intestinal dysbiosis, gut hyperpermeability and bacterial translocation: missing links between depression, obesity and type 2 diabetes

Slyepchenko, Anastasiya, Maes, Michael, Machado-Vieira, Rodrigo, Anderson, George, Solmi, Marco, Sanz, Yolanda, Berk, Michael, Köhler, Cristiano A. and Carvalho, Andre F. 2016, Intestinal dysbiosis, gut hyperpermeability and bacterial translocation: missing links between depression, obesity and type 2 diabetes, Current pharmaceutical design, vol. 22, no. 40, pp. 6087-6106, doi: 10.2174/1381612822666160922.

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Title Intestinal dysbiosis, gut hyperpermeability and bacterial translocation: missing links between depression, obesity and type 2 diabetes
Author(s) Slyepchenko, Anastasiya
Maes, Michael
Machado-Vieira, Rodrigo
Anderson, George
Solmi, Marco
Sanz, Yolanda
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Köhler, Cristiano A.
Carvalho, Andre F.
Journal name Current pharmaceutical design
Volume number 22
Issue number 40
Start page 6087
End page 6106
Total pages 22
Publisher Bentham Science Publishers
Place of publication Bussum, The Netherlands
Publication date 2016
ISSN 1873-4286
Keyword(s) microbiome
gut
probiotics
type 2 diabetes mellitus
obesity
metabolic syndrome
major depressive disorder
psychiatry
Summary The comorbid prevalence of major depressive disorder (MDD) with obesity and type II diabetes mellitus reflects the existence of a subset of individuals with a complex common pathophysiology and overlapping risk factors. Such comorbid disease presentations imply a number of difficulties, including: decreased treatment responsivity and adherence; altered glycemic control and increased risk of wider medical complications. A number of factors link MDD to metabolic-associated disorders, including: higher rates of shared risk factors such as poor diet and physical inactivity and biological elements including increased inflammation; insulin resistance; oxidative and nitrosative stress; and mitochondrial dysfunction. All of these biological factors have been extensively investigated in the pathophysiology of obesity and type 2 diabetes mellitus as well as MDD. In this review, we aim to: (1) overview the epidemiological links between MDD, obesity and type 2 diabetes mellitus; (2) discuss the role of synergistic neurotoxic effects in MDD comorbid with obesity, and type 2 diabetes mellitus; (3) review evidence of intestinal dysbiosis, leaky gut and increased bacterial translocation, in the pathophysiology of MDD, obesity and type 2 diabetes mellitus; and (4) propose a model in which the gut-brain axis could play a pivotal role in the comorbidity of these disorders.
Language eng
DOI 10.2174/1381612822666160922
Field of Research 110319 Psychiatry (incl Psychotherapy)
1115 Pharmacology And Pharmaceutical Sciences
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Bentham Science Publishers
Persistent URL http://hdl.handle.net/10536/DRO/DU:30091234

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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