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Redox control of antioxidant and antihepatotoxic activities of Cassia surattensis seed extract against paracetamol intoxication in mice: in vitro and in vivo studies of herbal green antioxidant

Uthaya Kumar, U. Seeta, Chen, Yeng, Kanwar, Jagat R. and Sasidharan, Sreeenivasan 2016, Redox control of antioxidant and antihepatotoxic activities of Cassia surattensis seed extract against paracetamol intoxication in mice: in vitro and in vivo studies of herbal green antioxidant, Oxidative medicine and cellular longevity, vol. 2016, pp. 1-13, doi: 10.1155/2016/6841348.

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Title Redox control of antioxidant and antihepatotoxic activities of Cassia surattensis seed extract against paracetamol intoxication in mice: in vitro and in vivo studies of herbal green antioxidant
Author(s) Uthaya Kumar, U. Seeta
Chen, Yeng
Kanwar, Jagat R.
Sasidharan, Sreeenivasan
Journal name Oxidative medicine and cellular longevity
Volume number 2016
Article ID 6841348
Start page 1
End page 13
Total pages 13
Publisher Hindawi Publishing Corporation
Place of publication Cairo, Egypt
Publication date 2016
ISSN 1942-0994
Summary The therapeutic potential of Cassia surattensis in reducing free radical-induced oxidative stress and inflammation particularly in hepatic diseases was evaluated in this study. The polyphenol rich C. surattensis seed extract showed good in vitro antioxidant. C. surattensis seed extract contained total phenolic content of 100.99 mg GAE/g dry weight and there was a positive correlation (r > 0.9) between total phenolic content and the antioxidant activities of the seed extract. C. surattensis seed extract significantly (p < 0.05) reduced the elevated levels of serum liver enzymes (ALT, AST, and ALP) and relative liver weight in paracetamol-induced liver hepatotoxicity in mice. Moreover, the extract significantly (p < 0.05) enhanced the antioxidant enzymes and glutathione (GSH) contents in the liver tissues, which led to decrease of malondialdehyde (MDA) level. The histopathological examination showed the liver protective effect of C. surattensis seed extract against paracetamol-induced histoarchitectural alterations by maximum recovery in the histoarchitecture of the liver tissue. Furthermore, histopathological observations correspondingly supported the biochemical assay outcome, that is, the significant reduction in elevated levels of serum liver enzymes. In conclusion, C. surattensis seed extract enhanced the in vivo antioxidant status and showed antihepatotoxic activities, which is probably due to the presence of phenolic compounds.
Language eng
DOI 10.1155/2016/6841348
Field of Research 111501 Basic Pharmacology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30091384

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.