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New synthetic approaches towards analogues of bedaquiline

Priebbenow, Daniel L., Barbaro, Lisa and Baell, Jonathan B. 2016, New synthetic approaches towards analogues of bedaquiline, Organic and biomolecular chemistry, vol. 14, no. 40, pp. 9622-9628, doi: 10.1039/c6ob01893a.

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Title New synthetic approaches towards analogues of bedaquiline
Author(s) Priebbenow, Daniel L.
Barbaro, Lisa
Baell, Jonathan B.
Journal name Organic and biomolecular chemistry
Volume number 14
Issue number 40
Start page 9622
End page 9628
Total pages 7
Publisher Royal Society of Chemistry
Place of publication Cambridge, Eng.
Publication date 2016-09-13
ISSN 1477-0520
1477-0539
Summary Multi-drug resistant tuberculosis (MDR-TB) is of growing global concern and threatens to undermine increasing efforts to control the worldwide spread of tuberculosis (TB). Bedaquiline has recently emerged as a new drug developed to specifically treat MDR-TB. Despite being highly effective as a result of its unique mode of action, bedaquiline has been associated with significant toxicities and as such, safety concerns are limiting its clinical use. In order to access pharmaceutical agents that exhibit an improved safety profile for the treatment of MDR-TB, new synthetic pathways to facilitate the preparation of bedaquiline and analogues thereof have been discovered.
Language eng
DOI 10.1039/c6ob01893a
Field of Research 030499 Medicinal and Biomolecular Chemistry not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Grant ID DP140103996
Copyright notice ©2016, Royal Society of Chemistry
Persistent URL http://hdl.handle.net/10536/DRO/DU:30091395

Document type: Journal Article
Collection: Faculty of Science, Engineering and Built Environment
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